Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Durvalumab with or without bevacizumab with transarterial chemoembolisation in hepatocellular carcinoma (EMERALD-1): a multiregional, randomised, double-blind, placebo-controlled, phase 3 study.
Lancet
January 2025
Department of Diagnostic and Interventional Radiology, University of Pisa School of Medicine, Pisa, Italy.
Background: Transarterial chemoembolisation (TACE) is standard of care for patients with unresectable hepatocellular carcinoma that is amenable to embolisation; however, median progression-free survival is still approximately 7 months. We aimed to assess whether adding durvalumab, with or without bevacizumab, might improve progression-free survival.
Methods: In this multiregional, randomised, double-blind, placebo-controlled, phase 3 study (EMERALD-1), adults aged 18 years or older with unresectable hepatocellular carcinoma amenable to embolisation, an Eastern Cooperative Oncology Group performance status of 0 or 1 at enrolment, and at least one measurable intrahepatic lesion per modified Response Evaluation Criteria in Solid Tumours (RECIST) were enrolled at 157 medical sites including research centres and general and specialist hospitals in 18 countries.
Ethical considerations for referral partnerships in clinical research.
J Med Ethics
December 2024
Department of Bioethics, The Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
Recruitment challenges in clinical research are widespread, particularly for traditionally under-represented groups. Referral relationships-in which research partners and clinical partners agree to collaborate on selected research studies or programmes, with the expectation that the clinical partners refer appropriate patients as potential participants-may help alleviate these challenges. Referral relationships allow research partners access to expanded and more diverse pools of participants by increasing the engagement of medical providers, leveraging providers' connections with patients and providing structural support for study participation.
View Article and Find Full Text PDFIt is not about autonomy: realigning the ethical debate on substitute judgement and AI preference predictors in healthcare.
J Med Ethics
November 2024
Interdepartmental Center for Research Ethics and Integrity (CID Ethics), National Research Council, Rome, Italy
Article Synopsis
- The article critiques two key assumptions in the ethical debate over algorithmic Personalised Patient Preference Predictors (P4) used for incapacitated patients: that a P4 can effectively respect the autonomy of patients without decision-making capacity, and that autonomy solely involves fulfilling a patient’s treatment preferences.
- The author argues that equating respect for autonomy with simply providing preferred treatments is flawed and that expanding our understanding of agency beyond a patient's direct decisions complicates clinical decision-making.
- The article proposes that the ethical discussion should focus on achieving broader moral goods through these tools, like honoring a patient's identity and alleviating the burden on surrogate decision-makers, thereby reshaping how we understand and justify substitute judgement in healthcare.
Patient and family perspectives on rural palliative care models: A systematic review and meta-synthesis.
Palliat Med
October 2024
IMPACCT (Improving Palliative, Aged and Chronic Care through Clinical Research and Translation), University of Technology Sydney, Sydney, NSW, Australia.
Background: Almost half the world's population lives in rural areas. How best to provide palliative care to rural populations is unclear. Privileging rural patient and family voices about their experiences of receiving care delivered via rural palliative care models is necessary.
View Article and Find Full Text PDFThe statue of Matron Alice Cashin (1870-1939).
J Med Biogr
September 2024
Faculty of Medicine, Kathmandu Medical College, Kathmandu, Nepal.
Article Synopsis
- - Alice Alanna Cashin (1870-1939) was an influential Australian nurse who dedicated her career to both wartime and humanitarian efforts, beginning her training at St. Vincent's Hospital, Sydney, before serving with the British Red Cross in WWI.
- - Her bravery was highlighted during a German U-Boat attack on the HMHS Gloucester Castle, where she led the evacuation of over 399 patients, earning multiple medals and accolades for her service.
- - After the war, Cashin returned to Australia to care for family, and her legacy continues with memorials in Woronora Cemetery and her medals displayed at the ANZAC Memorial in Sydney, honoring her contributions to nursing and healthcare.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!