A comparative trial of miringoplasty efficacy with or without application of biosynthetic wound cover Biocom-1 was performed in 82 patients with sub- and total chronic defects or acute traumatic rupture of the tympanic membrane (58 and 24 patients, respectively). Better clinico-morphological and functional results were achieved in patients treated with application of Biocom-1 (p<0.05). Their stay in hospital was also shorter. Biocom-1 not only provides stable position of the neotympanic membrane but also protects against secondary infection.
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