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Evidence to guide ethical decision-making in the management of older people living in squalor: a narrative review.
Intern Med J
August 2022
NHMRC Centre of Research Excellence in Healthy Housing, The Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Older people living in squalor present healthcare providers with a set of complex issues because squalor occurs alongside a variety of medical and psychiatric conditions, and older people living in squalor frequently decline intervention. To synthesise empirical evidence on squalor to inform ethical decision-making in the management of squalor using the bioethical framework of principlism. A systematic literature search was conducted using Medline, Embase, PsycINFO and CINAHL databases for empirical research on squalor in older people.
View Article and Find Full Text PDFDiogenes Syndrome: Identification and Distinction from Hoarding Disorder.
Case Rep Psychiatry
November 2021
Princess Elizabeth Hospital, The Oberlands Centre, La Rue de La Corbinnerie, St Martin, GY4 6SP Guernsey, UK.
"Severe domestic squalor" or Diogenes syndrome is characterised by extreme self-neglect of environment, health, and hygiene, excessive hoarding, squalor, social withdrawal, and a distinct lack of concern or shame regarding one's living condition. This report presents a case of a 51-year-old male admitted to the hospital psychiatric ward following the police removing him from his home. Police officers attended the man's home following the alarm being raised by his stepfather that he had not been seen or heard from in 3 weeks.
View Article and Find Full Text PDFAdipose-Derived Lipid-Binding Proteins: The Good, the Bad and the Metabolic Diseases.
Int J Mol Sci
September 2021
Inserm, UMR 1297, Institute of Metabolic and Cardiovascular Diseases (I2MC), 31432 Toulouse, France.
Adipose tissue releases a large range of bioactive factors called adipokines, many of which are involved in inflammation, glucose homeostasis and lipid metabolism. Under pathological conditions such as obesity, most of the adipokines are upregulated and considered as deleterious, due to their pro-inflammatory, pro-atherosclerotic or pro-diabetic properties, while only a few are downregulated and would be designated as beneficial adipokines, thanks to their counteracting properties against the onset of comorbidities. This review focuses on six adipose-derived lipid-binding proteins that have emerged as key factors in the development of obesity and diabetes: Retinol binding protein 4 (RBP4), Fatty acid binding protein 4 (FABP4), Apolipoprotein D (APOD), Lipocalin-2 (LCN2), Lipocalin-14 (LCN14) and Apolipoprotein M (APOM).
View Article and Find Full Text PDFVitamin D and bone health status in beta thalassemia patients-systematic review.
Osteoporos Int
June 2021
School of Medicine, European University Cyprus, Diogenes Street 6, Strovolos, 2404, Nicosia, Cyprus.
Thalassemia is a chronic congenital disease characterized by a combination of endocrine and metabolic disorders. Bone disease is a very common complication related to the poor absorption of calcium, the secondary chronic renal disease with low vitamin D, as well as multiple endocrine risk factors. The aim of this systematic review was to estimate the prevalence of vitamin D deficiency in thalassemia, as well as its association with osteoporosis/low bone mass.
View Article and Find Full Text PDFPayers' Views of the Changes Arising through the Possible Adoption of Adaptive Pathways.
Front Pharmacol
September 2016
Health Economics Centre, University of Liverpool Management SchoolLiverpool, UK; Department of Pharmacoepidemiology, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of StrathclydeGlasgow, UK; Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital HuddingeStockholm, Sweden.
Payers are a major stakeholder in any considerations and initiatives concerning adaptive licensing of new medicinal products, also referred to as Medicines Adaptive Pathways to patients (MAPPs). Firstly, the scope and necessity of MAPPs need further scrutiny, especially with regard to the definition of unmet need. Conditional approval pathways already exist for new medicines for seriously debilitating or life-threatening diseases and only a limited number of new medicines are innovative.
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