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The incidence of outpatient care within 24 months from SARS-CoV-2 infection in the general population: a multicenter population-based cohort study.
BMC Infect Dis
January 2025
Department of innovation in healthcare and social services, Emilia-Romagna Region, Bologna, Italy.
Background: The long-term effects of COVID-19, which can vary significantly in type and timing, are considered relevant and impacting on the well-being of individuals. The present study aims to assess the incidence of outpatient care in the post-acute phase of SARS-CoV-2 infection in two Italian regions.
Methods: The study has a multicentre, population-based, pre-post, repeated measures design to compare the incidence rate of access to outpatient visits and diagnostics before and after SARS-CoV-2 infection, considering a follow-up of 24 months.
Long-Term Stabilized and Highly Soluble Bezafibrate-Gliclazide Co-Amorphous Binary System.
AAPS PharmSciTech
January 2025
School of Engineering and Sciences, Tecnologico de Monterrey, Campus Monterrey, Ave. Eugenio Garza Sada 2501 Sur, C.P. 64849, Monterrey, N.L., Mexico.
Metabolic syndrome (MS) has a high prevalence, with an estimated one-quarter of the world population affected by this pathological condition. Among the diseases of this syndrome are dysregulation of lipids, hypertension, and insulin resistance. Unfortunately, available drugs in the market used for treating MS, as almost 75% of all drugs, are highly insoluble, presenting a significant demand for strategies to increase their solubility.
View Article and Find Full Text PDFUltrasound-Activated Copper Matrix Nanosonosensitizer for Cuproptosis-Based Synergy Therapy.
ACS Appl Bio Mater
January 2025
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China.
Cuproptosis exhibits enormous application prospects in treatment. However, cuproptosis-based therapy is impeded by the limited intracellular copper ions, the nonspecific delivery, uncontrollable release, and chelation of endogenous overproduced glutathione (GSH). In this work, an ultrasound-triggered nanosonosensitizer (p-TiO-Cu(I)) was constructed for Cu(I) delivery, on-demand release, GSH consumption, and deeper tissue response.
View Article and Find Full Text PDFA comprehensive review of factors affecting growth and secondary metabolites in hydroponically grown medicinal plants.
Planta
January 2025
Department of Biotechnology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, India.
Optimizing environmental factors can significantly increase the growth and secondary metabolite synthesis of hydroponically grown medicinal plants. This approach can help increase the quality and quantity of pharmacologically important metabolites to enhance therapeutic needs. Medicinal plants are key therapeutic sources for treating various ailments.
View Article and Find Full Text PDFDirect repeat region 3' end modifications regulate Cas12a activity and expand its applications.
Nucleic Acids Res
January 2025
Guangdong Provincial Key Laboratory of Digestive Cancer Research, Digestive Diseases Center, Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong 518107, P.R. China.
CRISPR-Cas12a technology has transformative potential, but as its applications grow, enhancing its inherent functionalities is essential to meet diverse demands. Here, we reveal a regulatory mechanism for LbCas12a through direct repeat (DR) region 3' end modifications and de-modifications, which can regulate LbCas12a's cis- and trans-cleavage activities. We extensively explored the effects of introducing phosphorylation, DNA, photo-cleavable linker, DNA modifications at the DR 3' end on LbCas12a's functionality.
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