AI Article Synopsis
- The B chain of ricin was introduced into tobacco protoplasts and degraded over time in the endoplasmic reticulum.
- This degradation did not occur in the vacuoles or during the secretion of the ricin B chain.
- Evidence suggests that, unlike the ricin A chain which is degraded in the cytosol, most of the ricin B chain is broken down in the secretory pathway.
Article Abstract
The B chain of ricin was expressed and delivered to the endoplasmic reticulum of tobacco protoplasts where it disappeared with time in a manner consistent with degradation. This turnover did not occur in the vacuoles or upon secretion. Indeed, several lines of evidence indicate that, in contrast to the turnover of endoplasmic reticulum-targeted ricin A chain in the cytosol, the bulk of expressed ricin B chain was degraded in the secretory pathway.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586253 | PMC |
| http://dx.doi.org/10.1074/jbc.M805222200 | DOI Listing |
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