Since November 2007, an increase in the number of reported hepatitis A cases has been observed in Latvia. The aim of this report is to provide an update on the descriptive epidemiology of hepatitis A in Latvia and suggest some possible explanations of the recent increase in incidence.
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http://dx.doi.org/10.2807/ese.13.40.18995-en | DOI Listing |
Euro Surveill
November 2024
Department of Infectious Disease Epidemiology, Robert Koch Institute (RKI), Berlin, Germany.
BackgroundHepatitis A and B vaccinations are recommended for men who have sex with men (MSM), given their increased risk of infection. However, data on vaccination programmes are scarce.AimTo use information on vaccination recommendations and vaccine uptake among MSM in the WHO European Region to guide prevention.
View Article and Find Full Text PDFLancet Infect Dis
October 2024
Division of Communicable Diseases, Environment, and Health, WHO Regional Office for Europe, Copenhagen, Denmark.
Background: In 2020, WHO guidelines prioritised the use of a standard fully oral short treatment regimen (STR) consisting of bedaquiline, levofloxacin or moxifloxacin, ethionamide, ethambutol, high-dose isoniazid, pyrazinamide, and clofazimine for the management of rifampicin-resistant tuberculosis. A high prevalence of resistance to constituent drugs precluded its widespread use by countries in the WHO European region. We evaluated three 9-month fully oral modified STRs (mSTRs) in which ethionamide, ethambutol, isoniazid, and pyrazinamide were replaced by linezolid, cycloserine, or delamanid (or a combination).
View Article and Find Full Text PDFVaccines (Basel)
March 2024
Latvian Biomedical Research and Study Centre, Ratsupites 1, LV-1067 Riga, Latvia.
Virus-like particles (VLPs) offer an attractive possibility for the development of vaccines. Recombinant core antigen (HBc) of Hepatitis B virus (HBV) was expressed in different systems, and the expression system was shown to be effective for the production of HBc VLPs. Here, we used HBc of the HBV genotype G (HBc/G) as a technologically promising VLP carrier for the presentation of spike RBM and nucleocapsid protein-derived peptides of the SARS-CoV-2 Delta variant for subsequent immunological evaluations of obtained fusion proteins.
View Article and Find Full Text PDFLancet Reg Health Eur
January 2024
Medical School, University of Cyprus, Nicosia, Cyprus.
J Med Case Rep
December 2023
Radiology Department, Riga East University Clinical Hospital, Stradins University, Hippocrates Street 2, Riga, 1038, Latvia.
Background: Pregnancy after liver transplantation poses a significant challenge to both the patient and the transplant team.
Case Presentation: We present the case of a 19-year-old European patient who underwent liver transplantation 5 years previously owing to autoimmune hepatitis. Poor compliance with immunosuppressive therapy and missed follow-up visits during the patient's first pregnancy likely contributed to her liver function deterioration, hospitalization, and failed pregnancy.
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