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This study investigated pregnane X receptor polymorphisms in relation to unboosted atazanavir plasma concentrations in 2 cohorts of patients. The polymorphism 63396T-->C predicted concentrations below the minimum effective concentration (150 ng/mL) with odds ratios of 18 (P = .008) and 5.13 (P = .02). Prospective studies determining potential clinical usefulness are now warranted.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672984 | PMC |
| http://dx.doi.org/10.1086/592304 | DOI Listing |
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