Objective: To investigate the potential for maximizing organ and tissue donation by identifying an empirical basis for structuring donor discussions.
Design: Intentions to donate organs and tissues were recorded in 2 separate samples of participants and analyzed separately by using Guttman scaling, the second sample providing a replication of the findings from the first.
Participants: 304 participants were recruited from the Royal Society Summer Science Exhibition 2004, and 200 health professionals were recruited from the Royal Free Hospital. RESULTD: High coefficients of scalability and reproducibility in both samples indicate a one-dimensional scale for intentions to donate organs and tissues, with solid organs more likely to be donated than corneal, hand, and facial tissue. Thus donor discussions can be structured in a robust order, with the potential for reliable use of cutoff points once donation of a particular organ or tissue has been refused.
Conclusions: This reliable pattern can be used to maximize organ and tissue donation rates and to underpin emergent transplant techniques.
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http://dx.doi.org/10.1177/152692480801800302 | DOI Listing |
Autoimmunity
December 2025
Spine Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Ankylosing Spondylitis (AS) and Systemic Sclerosis (SSc) are both autoimmune diseases, albeit with distinct anatomical targets. AS primarily affects the spine and sacroiliac joints, triggering inflammation and eventual fusion of the vertebrae. SSc predominantly impacts the skin and connective tissues, leading to skin fibrosis, thickening, and potential damage to vital organs such as the lungs, heart, and kidneys.
View Article and Find Full Text PDFIn Silico Pharmacol
December 2024
Department of Microbiology, Panjab University, Chandigarh, 160014 India.
Unlabelled: , an opportunistic and notorious nosocomial pathogen, is responsible for many infections affecting soft tissues, skin, lungs, bloodstream, and urinary tract, accounting for more than 722,000 cases annually. Despite the numerous advancements in therapeutic options, no approved vaccine is currently available for this particular bacterium. Consequently, this study focused on creating a rational vaccine design using bioinformatics tools.
View Article and Find Full Text PDFJOR Spine
December 2024
Trinity Centre for Biomedical Engineering Trinity Biomedical Sciences Institute, Trinity College Dublin, The University of Dublin Dublin Ireland.
Background: Low back pain (LBP) is predominantly caused by degeneration of the intervertebral disc (IVD) and central nucleus pulposus (NP) region. Conservative treatments fail to restore disc function, motivating the exploration of nucleic acid therapies, such as the use of microRNAs (miRNAs). miRNAs have the potential to modulate expression of discogenic factors, while silencing the catabolic cascade associated with degeneration.
View Article and Find Full Text PDFFront Nutr
December 2024
Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.
High sugar, high-fat diets and unhealthy lifestyles have led to an epidemic of obesity and obesity-related metabolic diseases, seriously placing a huge burden on socio-economic development. A deeper understanding and elucidation of the specific molecular biological mechanisms underlying the onset and development of obesity has become a key to the treatment of metabolic diseases. Recent studies have shown that the changes of bile acid composition are closely linked to the development of metabolic diseases.
View Article and Find Full Text PDFFront Physiol
December 2024
Department of Medical Physics and Medical Informatics, University of Szeged, Szeged, Hungary.
Introduction: Cerebral ischemia leads to multiple organ dysfunctions, with the lungs among the most severely affected. Although adverse pulmonary consequences contribute significantly to reduced life expectancy after stroke, the impact of global or focal cerebral ischemia on respiratory mechanical parameters remains poorly understood.
Methods: Rats were randomly assigned to undergo surgery to induce permanent global cerebral ischemia (2VO) or focal cerebral ischemia (MCAO), or to receive a sham operation (SHAM).
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