AI Article Synopsis
- The study aims to analyze glycine (Gly) levels in different grades of gliomas using (1)H MR spectroscopic imaging (MRSI) and distinguishes Gly from myoinositol (MI) based on their signal behaviors at short and long echo times.
- The research included MRSI performed on 29 glioma patients and five healthy subjects, revealing that higher-grade gliomas exhibited significantly increased Gly concentrations compared to lower-grade gliomas.
- The findings suggest that advanced MRSI techniques can effectively differentiate and quantify Gly and MI in gliomas and indicate that Gly could serve as a marker for tumor malignancy.
Article Abstract
Object: To investigate glycine (Gly) concentrations in low- and high-grade gliomas based on (1)H MR spectroscopic imaging (MRSI) with short and long echo time (TE). Myoinositol (MI) and Gly appear at the same resonance frequency of 3.56 ppm, but due to strong coupling the MI signal dephases more rapidly. Therefore, their contribution to the 3.56 ppm signal should be distinguishable comparing MRSI data acquired at short and long TE.
Materials And Methods: (1)H MRSI (TE = 30 and 144 ms) was performed at 3 T in 29 patients with histopathological confirmed World Health Organization (WHO) grade II-IV gliomas and in FIVE healthy subjects. All spectra from the gliomas revealed increase of the 3.56 ppm resonance in the short TE spectra. Signal intensities of Gly and MI were differentiated either by analysing the short to long TE ratio of the resonance or by performing a weighted difference. Gly concentrations were compared between high-grade (WHO III-IV) and low-grade gliomas.
Results: High-grade gliomas showed significantly higher Gly concentrations compared to low-grade gliomas.
Conclusion: Appropriate data processing of short and long TE (1)H MRSI provides a tool to distinguish and to quantify Gly and MI concentrations in gliomas. As Gly seems to be a marker of malignancy, more dedicated spectroscopic methods to differentiate these metabolites are justified.
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| http://dx.doi.org/10.1007/s10334-008-0145-z | DOI Listing |
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