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Cutting through the noise: A narrative review of Alzheimer's disease plasma biomarkers for routine clinical use.
J Prev Alzheimers Dis
January 2025
Clinical Memory Research Unit, Clinical Sciences in Malmö, Lund University, Lund, Sweden; Memory Clinic, Skåne University Hospital, Sweden. Electronic address:
As novel, anti-amyloid therapies have become more widely available, access to timely and accurate diagnosis has become integral to ensuring optimal treatment of patients with early-stage Alzheimer's disease (AD). Plasma biomarkers are a promising tool for identifying AD pathology; however, several technical and clinical factors need to be considered prior to their implementation in routine clinical use. Given the rapid pace of advancements in the field and the wide array of available biomarkers and tests, this review aims to summarize these considerations, evaluate available platforms, and discuss the steps needed to bring plasma biomarker testing to the clinic.
View Article and Find Full Text PDFBiosynthetic small molecule antigens mimics medicated lateral flow immunoassay for mycotoxin Fumonisin B using nanobody fusion proteins.
J Hazard Mater
January 2025
State Key Laboratory of Food Science and Resources, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China; Sino-German Joint Research Institute, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China; In Vitro Diagnostic Technology Innovation Center for Nanobody, No. 1166 Yiyuan Road, Nanchang, Jiangxi Province 330038, China; International Institute of Food Innovation Co., Ltd., Nanchang University, Luozhu Road, Nanchang 330200, China. Electronic address:
Lateral flow immunoassays (LFAs) are widely used in point-of-care testing (POCT) for detecting small molecules. However, their application is often hindered by the complex synthesis of traditional chemically synthesized antigens. Nanobody-based coating antigen mimics have shown excellent analytical performance in various immunoassay platforms, but their application in LFAs still faces challenges.
View Article and Find Full Text PDFNovel pain assessment tool specific for pulp symptoms to aid diagnosis.
Int Endod J
January 2025
Division of Conservative Dentistry and Endodontics, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India.
Aim: Although many pain assessment tools exist, none are specific to the relatively unique presentation of pulpal pain. The aim of this study was to develop and validate a novel pain assessment tool based on pulp symptoms.
Methodology: A preliminary list of items best-describing pulpitis was developed based on deductive and inductive approaches and the preliminary tool was piloted (n = 80).
A SERS/colorimetric biosensor based on AuNSs@Ag core-shell Prussian blue nanozyme for non-interference and rapid detection of Staphylococcus aureus in milk.
Mikrochim Acta
January 2025
College of Chemistry and Chemical Engineering, Xinjiang Normal University, Urumqi, 830054, China.
A AuNSs@PB@Ag-Apt surface-enhanced Raman scattering (SERS) probe has been developed by embedding Prussian blue (PB) between Au core and Ag shell. The PB SERS probe illustrates strong SERS activity in the Raman silent region of 2070 cm, and has a zero background signal, ensuring high sensitivity for the detection of Staphylococcus aureus (S. aureus).
View Article and Find Full Text PDFBiomarkers in coronary artery disease: systematic review and meta-analysis.
Future Cardiol
January 2025
Nanomaterial and Devices Laboratory, School of Engineering, Computing and Mathematics, Faculty of Science and Technology, University of Plymouth, Plymouth, Devon, UK.
Introduction: Little information exists regarding the detection of early coronary heart disease protein biomarkers. The aim of this study was to investigate several potential candidates.
Methods: Systematic review was carried out followed by meta-analysis.
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