Objective: Evidence-based practice recommendations abound, but implementation is often unstructured and poorly audited. We assessed the ability of a peer network to implement an evidence-based best practice protocol and to measure patient outcomes.
Design: Consensus definition of spontaneous breathing trial followed by implementation in eight academic medical centers.
Setting: Six medical, two surgical, and two combined medical/surgical adult intensive care units among eight academic medical centers.
Study Population: Patients initiating mechanical ventilation through an endotracheal tube during a 12-wk interval formed the study population.
Interventions: Adoption and implementation of a common spontaneous breathing trial protocol across multiple intensive care units.
Measurements And Main Results: Seven hundred five patients had 3,486 safety screens for conducting a spontaneous breathing trial; 2072 (59%) patients failed the safety screen. Another 379 (11%) patients failed a 2-min tolerance screen and 1,122 (34%) patients had a full 30-120 min spontaneous breathing trial performed. Seventy percent of eligible patients were enrolled. Only 55% of passing spontaneous breathing trials resulted in liberation from mechanical ventilatory support before another spontaneous breathing trial was performed.
Conclusions: Peer networks can be effective in promoting and implementing evidence-based best practices. Implementation of a best practice (spontaneous breathing trial) may be necessary for, but by itself insufficient to achieve, consistent and timely liberation from ventilator support.
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http://dx.doi.org/10.1097/ccm.0b013e3181872833 | DOI Listing |
J Surg Case Rep
January 2025
General Surgery Department, Al Noor Specialist Hospital, 3rd Ring Rd, 24241, Makkah, Saudi Arabia.
This case report discusses a 32-year-old woman with no significant medical history who underwent elective bilateral breast reduction with auto-augmentation and abdominoplasty. Initially, her recovery was smooth, but on the third postoperative day, she exhibited tachycardia, tachypnea, and mild shortness of breath, while other vital signs remained stable. A chest X-ray revealed pneumoperitoneum, and a subsequent abdominal CT confirmed moderate pneumoperitoneum without gastrointestinal leakage.
View Article and Find Full Text PDFJA Clin Rep
December 2024
Department of Anesthesiology, Niigata University Medical and Dental Hospital, 1-754 Asahimachi-Dori, Chuo-Ku, Niigata, 951-8520, Japan.
Background: Non-ketotic hyperglycinemia (NKH) is a rare autosomal recessive disorder caused by defects in the glycine cleavage system, leading to elevated glycine levels in the central nervous system. NKH manifests in various forms, with the neonatal type being the most severe and often associated with high mortality and significant neurological impairment. This case report highlights the successful uses of desflurane and nitrous oxide for anesthetic management in a patient with NKH.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
December 2024
Department of Ophthalmology, Aarhus University Hospital, Aarhus, Denmark.
Purpose: Previous in vitro studies on porcine retinal arterioles have shown that the frequency and amplitude of retinal vasomotion can be affected by hypoxia and nitric oxide (NO). However, it is unknown whether these effects can be reproduced in humans in vivo.
Methods: Video recordings of retinal arterioles from 40 healthy subjects were studied before and during breathing of a hypoxic gas mixture consisting of 12.
J Neurotrauma
December 2024
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Traumatic brain injury (TBI) after high-energy, behind helmet blunt trauma (BHBT) is an important but poorly understood clinical entity often associated with apnea and death in humans. In this study, we use a swine model of high-energy BHBT to characterize key neuropathologies and their association with acute respiratory decompensation. Animals with either stable or critical vital signs were euthanized within 4 h after injury for neuropathological assessment, with emphasis on axonal and vascular pathologies in the brainstem.
View Article and Find Full Text PDFPhysiol Behav
December 2024
State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Electronic address:
Object: This study aimed to investigate the physiological responses of patients with severe Chronic Obstructive Pulmonary Disease (COPD) during incremental expiratory resistive loading (ERL).
Method: Nine stable subjects with very severe COPD and hypercapnia were recruited. Baseline data were collected through spontaneous breathing for 10 minutes without resistive load.
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