AI Article Synopsis
- Automated electrophysiological assays play a crucial role in drug discovery, with advancements leading to practical devices for this purpose.
- The Roboocyte automated workstation, developed by Multi Channel Systems in collaboration with Bayer Technology Services, facilitates two-electrode voltage-clamp (TEVC) recording from Xenopus oocytes, making the process more efficient.
- The text outlines the technology's benefits and drawbacks compared to traditional methods and provides detailed operating procedures to highlight its effectiveness in an industrial context.
Article Abstract
Automated electrophysiological assays are of great importance for modern drug discovery, and various approaches have been developed into practical devices. Here, we describe the automation of two-electrode voltage-clamp (TEVC) recording from Xenopus oocytes using the Roboocyte automated workstation, jointly developed by Multi Channel Systems and Bayer Technology Services. We briefly discuss the technology, including its advantages and limitations relative to patch clamp and other TEVC systems. We provide a step-by-step description of typical operating procedures and show that the Roboocyte represents a practical and highly effective way to perform automated electrophysiology in an industrial setting.
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| http://dx.doi.org/10.1007/978-1-59745-529-9_6 | DOI Listing |
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The roboocyte: automated electrophysiology based on Xenopus oocytes.
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Automated electrophysiological assays are of great importance for modern drug discovery, and various approaches have been developed into practical devices. Here, we describe the automation of two-electrode voltage-clamp (TEVC) recording from Xenopus oocytes using the Roboocyte automated workstation, jointly developed by Multi Channel Systems and Bayer Technology Services. We briefly discuss the technology, including its advantages and limitations relative to patch clamp and other TEVC systems.
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