AI Article Synopsis
- The author studied the toxic properties of different pertussis strains by injecting albino mice with crude and heated suspensions and measuring weight changes.
- The analysis included 17 strains, focusing on the effects of thermostable dermonecrotic toxin and endotoxin, which showed consistent toxicity compared to other factors.
- No correlation was found between the toxicity of the strains and their serological types, and the toxic activity remained in strains kept in dried conditions.
Article Abstract
For the purpose of studying the toxic properties of pertussis strains with different agglutination composition and to ascertain the interrelationship between the action of the toxic substances and the serological type of the strains the author used a test of the weight change in albino mice to which crude and heated (at 56 degrees C for 10 minutes) suspensions of the strains of various serological types were injected intraperitoneally. The toxic properties were checked in 17 strains. The test of the change of the animal body weight with the determination of the regression coefficient permitted to determine roughly the presence of the toxic substances in the strains; the action of the thermostable dermonecrotic toxin and thermostable endotoxin was expressed with greater constancy than that of the lymphocytosis stimulating factor. There was no interrelationship between the manifestation of the action of toxic substances in the pertussis strains and their serological type. The toxic activity peristed in the strains stored in dried condition.
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