Objective: The goal of this study was to determine the effect of cement mixing time and, hence, cement viscosity on the biomechanical behavior of femoral fracture fixation.
Design: Cadaveric plated canine femoral fracture model, comparing treatments in matched pairs.
Setting: Orthopaedic biomechanics laboratory.
Intervention: Cement was inserted both as a liquid and as a paste in standard and oversized screw holes to augment fixation with plates and screws.
Main Outcome Measurements: Standard 4-point bending tests were performed to obtain stiffness and failure load values.
Results: Liquid cement had a 1.38 times increase in stiffness and a failure load 1.84 times greater compared with paste cement, regardless of hole size with a gap at the fracture site (P < 0.05). Liquid cement had a force to failure of 1.77 and 1.91 times in the standard-sized and oversized holes, respectively, when compared with paste cement (P < 0.05).
Conclusions: When the cement was inserted in a liquid state in a plated femoral diaphyseal fracture with a gap, screw purchase augmentation achieved greater bending stiffness and resisted a greater failure load.
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http://dx.doi.org/10.1097/BOT.0b013e31817e49d1 | DOI Listing |
Biomater Adv
December 2024
College of Biological Science and Engineering, Fuzhou University, No. 2 Xueyuan Road, Fuzhou 350108, China; Fujian Key Laboratory of Medical Instrument and Pharmaceutical Technology, Fuzhou University, No. 2 Xueyuan Road, Fuzhou 350108, China. Electronic address:
In anterior cruciate ligament (ACL) repair methods, the continuous enzymatic erosion of synovial fluid can impede healing and potentially lead to repair failure, as well as exacerbate articular cartilage wear, resulting in joint degeneration. Inspired by the blood clot during medial collateral ligament healing, we developed a composite scaffold comprising collagen (1 %, w/v) and polyvinyl alcohol (5 %, w/v) combined with platelet-rich plasma (PRP). The composite scaffold provides a protective barrier against synovial erosion for the ruptured ACL, while simultaneously facilitating tissue repair, thereby enhancing the efficacy of ACL repair techniques.
View Article and Find Full Text PDFBMC Oral Health
January 2025
Department of Conservative Dentistry, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
Background: Conservative dentistry introduced modern restoration designs, contributing to the greater use of partial-coverage ceramic restorations. New strong bondable ceramic materials made fabricating partial coverage ceramic restorations easier to restore the badly destructed teeth.
Aim Of The Study: This study investigated the impact of three distinct overlay preparation designs on the marginal fit (both before and after thermal aging) and the fracture resistance of overlay restorations fabricated using advanced zirconia-reinforced lithium disilicate (ALD) CAD/CAM glass-ceramic blocks.
J Orthop Surg Res
January 2025
Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China.
Background: Finite element analysis (FEA) could advance the understanding of fracture fixation and guide the choice of surgical treatment. This study aimed to compare two internal fixation methods in the treatment of displaced proximal humeral fracture (PHF) through FEA.
Methods: Three-dimensional FEA model based on the left shoulder joint of a 67-year-old female patient with PHFs and osteoporosis was adopted, in order to analyze the fixation effect and load stress distribution of internal fixation plates with open reduction and intramedullary nails without opening the fracture in the treatment of Neer III-VI PHF.
Nat Genet
January 2025
Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Aberrant immune responses to viral pathogens contribute to pathogenesis, but our understanding of pathological immune responses caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets of 6,321 Japanese individuals, including patients with autoimmune diseases (psoriasis vulgaris, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), pulmonary alveolar proteinosis (PAP) or multiple sclerosis) and coronavirus disease 2019 (COVID-19), or healthy controls. We systematically quantified two constituents of the blood DNA virome, endogenous HHV-6 (eHHV-6) and anellovirus.
View Article and Find Full Text PDFSci Rep
January 2025
School of Civil Engineering and Architecture, Anhui University of Science and Technology, Huainan, 232001, Anhui, China.
To investigate the changes in the strength and deformation of the blast load-damaged sandstone roof plate under cyclic loading and unloading conditions at different confining pressures, a triaxial loading device was used to carry out graded cyclic unloading tests on specimens with different degrees of damage, and the test results were summarized. The effects of blast-load-induced damage, confining pressure and loading stage on the strength, cohesion, internal friction angle, residual strain and volumetric strain were analyzed. (1) Compared with that of the undamaged specimen at a confining pressure of 0 MPa, the peak stress reductions in the vibration-damaged and blast-damaged specimens were 4.
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