AI Article Synopsis
- The study examined 533 children in Peru over four years to see how different genotypes of Cryptosporidium spp. correlated with various clinical symptoms.
- C. hominis infections were linked to more severe symptoms like diarrhea, nausea, and vomiting, along with higher oocyst shedding, while other species only caused diarrhea.
- Different subtypes of C. hominis had distinct symptoms, but no specific risk factors were found to connect to certain genotypes or subtypes, highlighting their relationship with clinical manifestations.
Article Abstract
To determine whether clinical manifestations are associated with genotypes or subtypes of Cryptosporidium spp., we studied a 4-year longitudinal birth cohort of 533 children in Peru. A total of 156 infection episodes were found in 109 children. Data from first infections showed that C. hominis was associated with diarrhea, nausea, vomiting, general malaise, and increased oocyst shedding intensity and duration. In contrast, C. parvum, C. meleagridis, C. canis, and C. felis were associated with diarrhea only. C. hominis subtype families were identified (Ia, Ib, Id, and Ie); all were associated with diarrhea. Ib was also associated with nausea, vomiting, and general malaise. All C. parvum specimens belonged to subtype family IIc. Analysis of risk factors did not show associations with specific Cryptosporidium spp. genotypes or subtypes. These findings strongly suggest that Cryptosporidium spp. and subtypes are linked to different clinical manifestations in children.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2609889 | PMC |
| http://dx.doi.org/10.3201/eid1410.071273 | DOI Listing |
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