AI Article Synopsis
- The study investigated how mild hypobaric hypoxia affects anxiety-like behaviors in rats exposed to conditions simulating post-traumatic stress disorder (PTSD).
- Rats that experienced mild hypobaric hypoxia before or after severe stress showed reduced anxiety in behavioral tests compared to those that didn't undergo hypoxia.
- The antidepressant Paxil had a lesser anxiolytic effect and caused some negative side effects, suggesting that mild hypobaric hypoxia may be a promising drug-free option for managing PTSD symptoms.
Article Abstract
The impact of mild hypobaric hypoxia on the development of anxiety-like state in rats in experimentally simulated human post-traumatic stress disorder was studied. Three-trial exposure to mild hypobaric hypoxia (360 mm Hg for 2 hours daily, for 3 days) in preconditioning or post-conditioning mode performed, respectively, before or after exposure to severe traumatic stress in the "stress-restress" model produced a significant anxiolytic effect on the rat open-field and plus-maze behavior. Anxiolytic effect of modem antidepressant Paxil (20 mg/kg daily, for 3 days) was weaker. This drug produced side-effects on particular behavioral characteristics in the open field. The conclusion was made on the efficacy of mild hypobaric hypoxia and the possibility of its implementation as a medication-free tool for prophylaxis and correction of post-traumatic stress disorder.
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