AI Article Synopsis
- Thirteen epoxy resin system components were evaluated for skin sensitization using the Local Lymph Node Assay (LLNA), measuring lymph node stimulation through cell proliferation methods.
- All tested substances exhibited skin-sensitizing potential, generally falling between "strong" and "moderate" in potency classification when dissolved in acetone.
- Using a different vehicle (acetone/olive oil) for four selected substances resulted in much lower sensitization concentrations, highlighting difficulties in comparing results from various LLNA methods.
Article Abstract
Thirteen epoxy resin system components were tested in the LLNA with regard to their sensitizing potency. Lymph node stimulation was quantified not only by measuring the incorporation of [3H]-thymidine into the ear lymph nodes but also the counts of cells recovered from these organs. Equivalent figures were obtained with both endpoints used for the evaluation of lymph node cell proliferation if the reference stimulation indices were adjusted. When dissolved in acetone, all test substances showed skin-sensitizing potential, mainly on the boundary between "strong" and "moderate" according to common potency evaluation schemes. Replacing acetone with acetone/olive oil (4:1) as a vehicle for four selected test items, resulted in considerably lower estimated concentrations for sensitization induction. The challenges in comparing the results obtained by different LLNA variations are discussed.
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| http://dx.doi.org/10.1016/j.yrtph.2008.08.018 | DOI Listing |
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