Statin use and the risk of Parkinson disease: a nested case control study.

J Clin Neurosci

Department of Neurology, University of Washington, Seattle VA Parkinson Disease Research Education and Clinical Center (PADRECC), VA Puget Sound Health Care System, 1660 S. Columbian Way, MS-127, Seattle, WA 98108, USA.

Published: November 2008

Using the British Columbia Linked Health Databases, we explored the association between the use of statin drugs and the risk of developing Parkinson disease (PD). We followed a cohort of older adults in the Province of British Columbia from 1997 to 2003. Using a study design of nested case control (case-control study within a cohort), the relative risk of developing PD for statin users was 0.94 (0.82-1.09). Our study did not show a statistically significant effect on the risk of PD with statin use.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jocn.2008.01.016DOI Listing

Publication Analysis

Top Keywords

parkinson disease
8
nested case
8
case control
8
british columbia
8
risk developing
8
statin
4
statin risk
4
risk parkinson
4
disease nested
4
study
4

Similar Publications

Elevated CXCL1 triggers dopaminergic neuronal loss in the substantia nigra of C57BL/6J mice: Evaluation of a novel Parkinsonian mouse model.

Zool Res

January 2025

Institute of Brain Science and Disease, School of Basic Medicine, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, Shandong 266071, China. E-mail:

Substantial evidence points to the early onset of peripheral inflammation in the development of Parkinson's disease (PD), supporting the "body-first" hypothesis. However, there remains a notable absence of PD-specific animal models induced by inflammatory cytokines. This study introduces a novel mouse model of PD driven by the proinflammatory cytokine CXCL1, identified in our previous research.

View Article and Find Full Text PDF

[Neurorehabilitation in Parkinson's disease : focus on physical therapy].

Rev Med Suisse

January 2025

Service de neurologie, Clinique bernoise Montana, 3963 Crans-Montana.

Parkinson's disease affects around 6 million people worldwide. It causes both motor and non-motor symptoms. Since there is no cure, medical treatment aims to improve patients' quality of life.

View Article and Find Full Text PDF

Is the freezing index a valid outcome to assess freezing of gait during turning in Parkinson's disease?

Front Neurol

January 2025

Department of Rehabilitation Sciences, Neurorehabilitation Research Group (eNRGy), KU Leuven, Leuven, Belgium.

Introduction: Freezing of gait (FOG) is a disabling symptom for people with Parkinson's disease (PwPD). Turning on the spot for one minute in alternating directions (360 turn) while performing a cognitive dual-task (DT) is a fast and sensitive way to provoke FOG. The FOG-index is a widely used wearable sensor-based algorithm to quantify FOG severity during turning.

View Article and Find Full Text PDF

Traumatic brain injury is widely viewed as a risk factor for dementia, but the biological mechanisms underlying this association are still unclear. In previous studies, traumatic brain injury has been associated with the hallmark pathologies of Alzheimer's disease, i.e.

View Article and Find Full Text PDF

Asymmetric dopaminergic degeneration of the striatum is a characteristic feature of Parkinson's disease, associated with right-left asymmetry in motor function. As such, studying asymmetry provides insights into progressive neurodegeneration between cerebral hemispheres. Given the impact of Lewy pathology on various neurotransmitter systems beyond the dopaminergic, it may be that other neuronal systems in the predominantly affected hemisphere are similarly affected.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!