Hist Philos Life Sci
Department of Philosophy, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Published: October 2008
This paper is devoted to an examination of the discovery, characterization, and analysis of the functions of microRNAs, which also serves as a vehicle for demonstrating the importance of exploratory experimentation in current (post-genomic) molecular biology. The material on microRNAs is important in its own right: it provides important insight into the extreme complexity of regulatory networks involving components made of DNA, RNA, and protein. These networks play a central role in regulating development of multicellular organisms and illustrate the importance of epigenetic as well as genetic systems in evolution and development. The examination of these matters yields principled arguments for the historicity of the functions of key biological molecules and for the indispensability of exploratory experimentation in contemporary molecular biology as well as some insight into the complex interplay between exploratory experimentation and hypothesis-driven science. This latter result is not only important for philosophy of science, but also of practical importance for the evaluation of grant proposals, although the elaboration of this latter claim must be left for another occasion.
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Head Neck
January 2025
Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
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January 2025
Translational Brain Science, Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.
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Nurs Rep
January 2025
Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 287 Giuseppe Campi Street, 41125 Modena, Italy.
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View Article and Find Full Text PDFBiomimetics (Basel)
December 2024
Department of Computer Science, Durham University, Durham DH1 3LE, UK.
The RIME algorithm is a novel physical-based meta-heuristic algorithm with a strong ability to solve global optimization problems and address challenges in engineering applications. It implements exploration and exploitation behaviors by constructing a rime-ice growth process. However, RIME comes with a couple of disadvantages: a limited exploratory capability, slow convergence, and inherent asymmetry between exploration and exploitation.
View Article and Find Full Text PDFBiomimetics (Basel)
December 2024
Department of Mechanical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.
Despite technological advancements in various industries, the equine sector still relies on old methods like horseshoeing. Although traditional, the industry is dynamic and well-funded. Therefore, there is a need to modernize these methods with more reliable and less invasive solutions for attaching horseshoes to horse hooves.
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