AI Article Synopsis
- The study aimed to develop a new in situ gel system for delivering a medication (MF) for allergic rhinitis through the nasal route.
- The gel, made with gellan gum, remained stable for 6 months at 40 degrees Celsius and was found to be safe, with no irritation in rats even after daily dosing for a month.
- The findings showed that the gellan gum gel was more effective than standard liquid suspension in treating allergic rhinitis, indicating its potential as a better delivery method for MF.
Article Abstract
The main purpose of this study was to prepare a novel in situ gel system for nasal delivery of MF and study its efficacy on allergic rhinitis model. An ion-activated in situ gel was developed and characterized with gellan gum as a carrier. The system was stable kept at 40+/-2 degrees C for 6 months, and the micrographic results showed that in situ gel was safety without mucosa irritation when given at 20 microg once daily for 1 month to rats with allergic rhinitis. MF in gellan gum produced obviously effect on allergic rhinitis at the doses of 20 microg/body following intranasal administration, and the efficacy was significantly superior to that of the common suspension (P<0.01). The in situ gel system is a promising approach for the intranasal delivery of MF for the therapeutic effects improvement.
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| http://dx.doi.org/10.1016/j.ijpharm.2008.08.042 | DOI Listing |
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