AI Article Synopsis
- The study presents a method for creating new non-acidic NSAIDs from N-pyridinyl(methyl)indolylpropanamides.
- Pharmacomodulation was applied at specific sites on the indole ring and propanamide chain to enhance effectiveness.
- One of the synthesized compounds, N(3)-pyridinylmethyl-[1(4-chlorobenzyl-5-chloroindol-3-yl)propanamide], showed greater activity than ibuprofen and similar potency to dexamethasone in a mouse ear swelling test.
Article Abstract
In this study, the synthetic way to new N-pyridinyl(methyl)indolylpropanamides acting as non acidic NSAIDs has been described. Pharmacomodulation was carried out at N(1) and C(5) of the indole ring and at the level of the propanamide chain. N(3)-pyridinylmethyl-[1(4-chlorobenzyl-5-chloroindol-3-yl)propanamide represents one of the most potent compounds in the TPA-induced mouse ear swelling assay, with a level of activity higher than that of ibuprofen and comparable to that of dexamethasone.
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| http://dx.doi.org/10.1080/14756360802208251 | DOI Listing |
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