AI Article Synopsis
- A dynamic heterogeneous phase polymerization reaction effectively controls the cross-linking of hemoglobin with glutaraldehyde.
- The process results in narrow molecular weight distribution and low average molecular weight due to selective absorption and asymmetric protein concentration.
- Approximately 53% of hemoglobin is cross-linked with glutaraldehyde, yielding poly-hemoglobins predominantly in the molecular weight range of 128 kD to 258 kD.
Article Abstract
A dynamic heterogeneous phase polymerization reaction is found to be efficient for controllable cross-link of hemoglobin with glutaraldehyde. The selective absorption of the immobile phase and asymmetry of protein concentration leads to narrowness of the molecular weight distribution and lowness of the average molecular weight. Using this method, 53% of hemoglobin obtained is intermolecular cross-linked with 12 molecular equivalents of glutaraldehyde. The majority of poly-hemoglobins is in the range of 128 kD to 258 kD.
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| http://dx.doi.org/10.1080/10731190802375786 | DOI Listing |
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