RiceGeneThresher is a public online resource for mining genes underlying genome regions of interest or quantitative trait loci (QTL) in rice genome. It is a compendium of rice genomic resources consisting of genetic markers, genome annotation, expressed sequence tags (ESTs), protein domains, gene ontology, plant stress-responsive genes, metabolic pathways and prediction of protein-protein interactions. RiceGeneThresher system integrates these diverse data sources and provides powerful web-based applications, and flexible tools for delivering customized set of biological data on rice. Its system supports whole-genome gene mining for QTL by querying using DNA marker intervals or genomic loci. RiceGeneThresher provides biologically supported evidences that are essential for targeting groups or networks of genes involved in controlling traits underlying QTL. Users can use it to discover and to assign the most promising candidate genes in preparation for the further gene function validation analysis. The web-based application is freely available at http://rice.kps.ku.ac.th.
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http://dx.doi.org/10.1093/nar/gkn638 | DOI Listing |
Cancers (Basel)
January 2025
Department of Medical Oncology, Faculty of Medicine, İstinye University, İstanbul 34010, Turkey.
Background: Although higher-generation TKIs are associated with improved progression-free survival in advanced NSCLC patients with EGFR mutations, the optimal selection of TKI treatment remains uncertain. To address this gap, we developed a web application powered by a reinforcement learning (RL) algorithm to assist in guiding initial TKI treatment decisions.
Methods: Clinical and mutational data from advanced NSCLC patients were retrospectively collected from 14 medical centers.
J Cheminform
January 2025
Research Programme On Biomedical Informatics (GRIB), Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Hospital del Mar Medical Research Institute, Barcelona, Spain.
This article introduces StreamChol, a software for developing and applying mechanistic models to predict cholestasis. StreamChol is a Streamlit application, usable as a desktop application or web-accessible software when installed on a server using a docker container.StreamChol allows a seamless integration of pharmacokinetic analyses with Machine Learning models.
View Article and Find Full Text PDFSci Rep
January 2025
Nursing College, Jinzhou Medical University, Jinzhou, China.
Alexithymia, characterized by difficulty in expressing and recognizing emotions, is prevalent among young and middle-aged stroke survivors and can significantly impact rehabilitation outcomes. This study aims to develop and validate a dynamic nomogram to predict the risk of alexithymia in this population. This cross-sectional study was conducted from November 2022 to August 2023 at two tertiary hospitals in Jinzhou City and Cangzhou City, enrolling 319 patients.
View Article and Find Full Text PDFBMC Med Genomics
January 2025
Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, SE-751 85, Sweden.
Background: Noninvasive prenatal testing (NIPT) is increasingly used to screen for fetal chromosomal aneuploidy by analyzing cell-free DNA (cfDNA) in peripheral maternal blood. The method provides an opportunity for early detection of large genetic abnormalities without an increased risk of miscarriage due to invasive procedures. Commercial applications for use at clinical laboratories often take advantage of DNA sequencing technologies and include the bioinformatic workup of the sequence data.
View Article and Find Full Text PDFJ Expo Sci Environ Epidemiol
January 2025
Department of Veterinary Physiology & Pharmacology, Texas A&M University, College Station, TX, USA.
Background: Many chemical releases are first noticed by community members, but reporting these concerns often involves considerable hurdles. Artificial Intelligence (AI)-enabled technologies, especially large language models (LLMs), can potentially reduce these barriers.
Objective: We hypothesized that AI-powered chatbots can facilitate reporting of pollution incidents through text messaging.
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