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Increased Frequency of Circulating Activated FOXP3 Regulatory T Cell Subset in Patients with Chronic Lymphocytic Leukemia Is Associated with the Estimate of the Size of the Tumor Mass, STAT5 Signaling and Disease Course during Follow-Up of Patients on Therapy.
Cancers (Basel)
September 2024
Department of Laboratory Diagnostics, University Medical Centre Maribor, 2000 Maribor, Slovenia.
Article Synopsis
- Advanced chronic lymphocytic leukemia (CLL) leads to an increase in regulatory T cells (Tregs) and higher risk of severe infections, particularly linked to heightened FOXP3 expression in these cells.
- A study utilizing flow cytometry assessed STAT5 signaling in Treg subsets among 37 CLL patients, looking at how this related to disease progression and tumor mass.
- Findings indicated that a specific subset of activated Tregs (aTregs) was correlated with advanced disease and severe infection rates, suggesting aTreg levels could serve as a marker for disease severity and that increased STAT5 signaling may contribute to their expansion.
Article Synopsis
- * A study involving 781 untreated stage A CLL patients compared five different risk scoring methods to see which best predicted disease progression, also assessing the impact of including the IGHV2 subset as a poor prognostic factor.
- * All five risk scores performed similarly in identifying low to high-risk patients, with CLL-IPI showing the best results, and findings indicate that incorporating IGHV2 could enhance the accuracy of these risk assessments.
Demonstrating Agreement between Radio and Fluorescence Measurements of the Depth of Maximum of Extensive Air Showers at the Pierre Auger Observatory.
Phys Rev Lett
January 2024
Center for Astrophysics and Cosmology (CAC), University of Nova Gorica, Nova Gorica, Slovenia.
We show, for the first time, radio measurements of the depth of shower maximum (X_{max}) of air showers induced by cosmic rays that are compared to measurements of the established fluorescence method at the same location. Using measurements at the Pierre Auger Observatory we show full compatibility between our radio and the previously published fluorescence dataset, and between a subset of air showers observed simultaneously with both radio and fluorescence techniques, a measurement setup unique to the Pierre Auger Observatory. Furthermore, we show radio X_{max} resolution as a function of energy and demonstrate the ability to make competitive high-resolution X_{max} measurements with even a sparse radio array.
View Article and Find Full Text PDFAdditional lesions identified by genomic microarrays are associated with an inferior outcome in low-risk chronic lymphocytic leukaemia patients.
Br J Haematol
September 2023
Hematology Section, St. Anna University Hospital, Ferrara, Italy.
We explored the relevance of genomic microarrays (GM) in the refinement of prognosis in newly diagnosed low-risk chronic lymphocytic leukaemia (CLL) patients as defined by isolated del(13q) or no lesions by a standard 4 probe fluorescence in situ hybridization (FISH) analysis. Compared to FISH, additional lesions were detected by GM in 27 of the 119 patients (22.7%).
View Article and Find Full Text PDFElevated levels of circulatory follicular T helper cells in chronic lymphocytic leukemia contribute to B cell expansion.
J Leukoc Biol
March 2023
Immunoconcept, CNRS UMR 5164, Université de Bordeaux, 146 rue Leo Saignat, 33076 Bordeaux, France.
Article Synopsis
- * The study found increased levels of follicular helper T cells (Tfh) in untreated CLL patients, which were linked to more severe disease, as indicated by the Binet staging system.
- * Tfh cells in CLL patients showed an activated Th1-like phenotype and were found to promote B-CLL cell survival and proliferation through IL-21, while also showing an association with immune dysfunction in CLL, as suggested by the relationship with serum IgA and IgG levels.
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