AI Article Synopsis
- A small family of 2,4(5)-diarylimidazoles was synthesized using a straightforward method.
- One compound from this series showed significant inhibition of hNa(v)1.2 sodium channel currents.
- This compound is considered a promising candidate for further research to develop new sodium channel blockers.
Article Abstract
A small family of novel 2,4(5)-diarylimidazoles were prepared through a simple and efficient synthesis and evaluated as potential inhibitors of hNa(v)1.2 sodium channel currents. One member of this series (4) exhibited profound inhibition of Na(v)1.2 currents, emerging as a promising lead compound for further structure-activity relationship studies for the development of novel sodium channel blockers.
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| http://dx.doi.org/10.1016/j.bmcl.2008.09.036 | DOI Listing |
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