Linear polymers of PARACEST agents were prepared by using classical free radical chain polymerization conditions. The Eu3+-polymers exhibited similar intermediate-to-slow water exchange and CEST characteristics as the Eu3+-monomers. This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723842 | PMC |
| http://dx.doi.org/10.1021/ja805775u | DOI Listing |
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