AI Article Synopsis
- Two new cyathane-type diterpenoids have been isolated from a liquid culture of Strobilurus tenacellus, identified as two distinct compounds based on their chemical structures.
- The structures were characterized using advanced spectral methods including HR-EI-MS and NMR techniques.
- Both compounds exhibit antimicrobial activity, particularly against Pseudomonas aeruginosa, and compound 2 also demonstrates growth inhibition against certain human cancer cell lines (YMB and COLO 201).
Article Abstract
The structures of two new cyathane-type diterpenoids isolated from a liquid culture of Strobilurus tenacellus have been elucidated. The chemical structures of the new compounds 1 and 2 were identified as (12S)-11alpha,14alpha-epoxy-13alpha,14beta,15-trihydroxycyath-3-ene and (12R)-11alpha,14alpha-epoxy-13alpha,14beta,15-trihydroxycyath-3-ene, respectively, by spectral methods, including HR-EI-MS, and 1D- and 2D-NMR techniques. Compounds 1 and 2 show antimicrobial activity against Pseudomonas aeruginosa. In addition, both compounds were also tested for activity against human cancer cells, and 2 showed growth inhibitory activity against YMB and COLO 201 cells.
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| http://dx.doi.org/10.1002/cbdv.200890170 | DOI Listing |
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