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Micrococcus Peritonitis Complicating Peritoneal Dialysis.
R I Med J (2013)
February 2024
The Warren Alpert Medical School of Brown University; Department of Kidney and Hypertension, Rhode Island Hospital, Providence, RI.
Peritonitis, a serious complication of peritoneal dialysis (PD), can be caused by opportunistic pathogens like Micrococcus species on rare occasions. We present a case of Micrococcus sp peritonitis in a 55-year-old female with end-stage kidney disease on continuous cycling peritoneal dialysis for one year who presented with cloudy effluent. Initial treatment against Micrococcus sp with vancomycin, gentamicin, and prophylactic oral nystatin was successful.
View Article and Find Full Text PDFAntifungal Activity and Type of Interaction of Essential Oil with Antimycotics against Biofilms of Multidrug-Resistant Isolates from Vulvovaginal Mucosa.
J Fungi (Basel)
November 2023
Department of Biology, Faculty of Science and Mathematics, University of Nis, 18000 Nis, Serbia.
(1) Background: Vulvovaginal candidosis (VVC) is a major therapy issue due to its high resistance rate and virulence factors such as the ability to form biofilms. The possibility of combining commonly used antifungals with natural products might greatly improve therapeutic success. (2) Methods: A total of 49 vulvovaginal isolates, causative agents of recurrent VVC, were tested for their susceptibility to fluconazole, nystatin, and essential oil (MOEO).
View Article and Find Full Text PDFSuccessful treatment of experimental murine vulvovaginal candidiasis with gentian violet.
Future Microbiol
November 2023
Medical Mycology Laboratory, Clinical Analyzes & Biomedicine Department, State University of Maringa, Maringa, PR, 87020-900, Brazil.
This study evaluated the antifungal efficacy of gentian violet (GV) in an experimental vulvovaginal candidiasis (VVC) model. susceptibility and cytotoxicity assays were performed to validate the antifungal potential and safety of GV. The antifungal efficacy was then evaluated through comparative analysis of the fungal burden following treatment with GV or nystatin, as well as assessment of the vaginal tissue by histology and electron microscopy.
View Article and Find Full Text PDFImpact of Nystatin Oral Rinse on Salivary and Supragingival Microbial Community among Adults with Oral Candidiasis.
Microorganisms
June 2023
Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY 14627, USA.
This study aimed to evaluate the impact of Nystatin oral rinse on salivary and supragingival microbiota in adults with oral candidiasis and identify predictive factors related to individuals' responses to Nystatin. The trial involved twenty participants who used 600,000 International Units/application of Nystatin oral rinse for seven days, four times a day, and were followed up at one week and three months after the rinse. The salivary and plaque microbiome of the participants were assessed via 16S rDNA amplicon sequencing.
View Article and Find Full Text PDFAntifungals: From Pharmacokinetics to Clinical Practice.
Antibiotics (Basel)
May 2023
Advanced Unit for Pharmacokinetics and Personalized Therapeutics, Clinical Pathology Department, Centro Hospitalar e Universitário de Coimbra, 3004-561 Coimbra, Portugal.
The use of antifungal drugs started in the 1950s with polyenes nystatin, natamycin and amphotericin B-deoxycholate (AmB). Until the present day, AmB has been considered to be a hallmark in the treatment of invasive systemic fungal infections. Nevertheless, the success and the use of AmB were associated with severe adverse effects which stimulated the development of new antifungal drugs such as azoles, pyrimidine antimetabolite, mitotic inhibitors, allylamines and echinochandins.
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