In mice, targeted deletion of the basic helix-loop-helix transcription factor, nescient helix-loop-helix 2 (Nhlh2), leads to adult-onset obesity and reduced physical activity. We propose the novel hypothesis that transcriptional activity by Nhlh2 (NHLH2 in humans) controls either the ability or the motivation for exercise.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707263 | PMC |
| http://dx.doi.org/10.1097/JES.0b013e31818782dd | DOI Listing |
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