AI Article Synopsis
- A new series of modified macrolide derivatives has been created using a simple synthesis method.
- These derivatives were tested for their antibacterial effectiveness against strains of bacteria that are resistant to erythromycin.
- Among these tested compounds, 8a showed strong antibacterial activity against many of these resistant bacterial strains due to its unique chemical groups.
Article Abstract
A series of novel 4''-position modified macrolide derivatives has been synthesized via a facile procedure. Their in vitro antibacterial activities against constitutively erythromycin-resistant strains were evaluated. Among the derivatives tested, compound 8a which has 11,12-carbamate and 4''-O-heteroarylcarbamoyl groups was found to have potent activity against most resistant bacteria.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2008.09.022 | DOI Listing |
Publication Analysis
Top Keywords
synthesis antibacterial
4
antibacterial activity
4
activity 4''-o-heteroarylcarbamoyl
4
4''-o-heteroarylcarbamoyl derivatives
4
derivatives macrolide
4
macrolide series
4
series novel
4
novel 4''-position
4
4''-position modified
4
modified macrolide
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!