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Left-Sided Atrioventricular Valve Regurgitation After the Repair of Complete Atrioventricular Septal Defect.
Pediatr Cardiol
November 2024
Department of Pediatric Cardiac Surgery, Saitama Medical University International Medical Center, Hidaka, Saitama, 1397-1, Yamane350-1298, Japan.
Article Synopsis
- * The median age at repair was 5.5 months, with a follow-up period of 11 years showing a high survival rate of 96.4% and a 10-year freedom rate from moderate valve regurgitation at 58.4%.
- * Key findings indicated that complete closure of the left-sided atrioventricular valve cleft significantly reduced risk of moderate regurgitation, while incomplete cleft closure was linked to worsened valve conditions post-surgery.
Disrupted White Matter Topology Organization in Preschool Children with Tetralogy of Fallot.
Brain Behav
November 2024
Department of Radiology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Article Synopsis
- Cognitive impairment is a common issue in children with congenital heart disease (CHD), particularly in those with Tetralogy of Fallot (TOF), and this study explores how TOF affects brain network organization.
- The research involved 29 preschool-aged children with TOF and 19 without CHD, utilizing diffusion tensor imaging to analyze brain structures, revealing significant differences in network properties between the two groups.
- Key findings indicate that TOF children showed impaired brain connectivity and efficiency, which correlated with poorer cognitive performance, suggesting that disruptions in brain network integration could underlie cognitive deficits in these children.
NOTCH1 mitochondria localization during heart development promotes mitochondrial metabolism and the endothelial-to-mesenchymal transition in mice.
Nat Commun
November 2024
Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Notch signaling activation drives an endothelial-to-mesenchymal transition (EndMT) critical for heart development, although evidence suggests that the reprogramming of endothelial cell metabolism can regulate endothelial function independent of canonical cell signaling. Herein, we investigated the crosstalk between Notch signaling and metabolic reprogramming in the EndMT process. Biochemically, we find that the NOTCH1 intracellular domain (NICD1) localizes to endothelial cell mitochondria, where it interacts with and activates the complex to enhance mitochondrial metabolism.
View Article and Find Full Text PDFSpecial considerations for the stabilization and resuscitation of patients with cardiac disease in the Neonatal Intensive Care Unit.
Semin Perinatol
December 2024
Division of Neonatology, Department of Pediatrics, Stollery Children's Hospital/University of Alberta, Edmonton, AB, Canada.
Effective resuscitation of neonates with congenital heart disease (CHD) depends on comprehensive planning, thorough understanding of physiology, vigilant monitoring, and interdisciplinary collaboration to achieve the best outcomes. Neonatal heart disease can affect cardiac structure, rhythm, or ventricular function, and may be either congenital or acquired. Critical congenital heart disease (CCHD) can result in inadequate pulmonary blood flow, impaired intracardiac mixing, airway obstruction, or insufficient cardiac output.
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