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| http://dx.doi.org/10.1155/2008/764934 | DOI Listing |
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Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.
Circ Cardiovasc Interv
December 2024
Cardiovascular Clinical Research Center, Department of Medicine, NYU Grossman School of Medicine, New York, NY (H.R.R., L.P., S.B., J.S.H.).
Background: The relationship between the extent and severity of stress-induced ischemia and the extent and severity of anatomic coronary artery disease (CAD) in patients with obstructive CAD is multifactorial and includes the intensity of stress achieved, type of testing used, presence and extent of prior infarction, collateral blood flow, plaque characteristics, microvascular disease, coronary vasomotor tone, and genetic factors. Among chronic coronary disease participants with site-determined moderate or severe ischemia, we investigated associations between ischemia severity on stress testing and the extent of CAD on coronary computed tomography angiography.
Methods: Clinically indicated stress testing included nuclear imaging, echocardiography, cardiac magnetic resonance imaging, or nonimaging exercise tolerance test.
COVID-19 testing and reporting behaviours in England across different sociodemographic groups: a population-based study using testing data and data from community prevalence surveillance surveys.
Lancet Digit Health
November 2024
Department of Statistics, University of Oxford, Oxford, UK; College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK. Electronic address:
Background: Understanding underlying mechanisms of heterogeneity in test-seeking and reporting behaviour during an infectious disease outbreak can help to protect vulnerable populations and guide equity-driven interventions. The COVID-19 pandemic probably exerted different stresses on individuals in different sociodemographic groups and ensuring fair access to and usage of COVID-19 tests was a crucial element of England's testing programme. We aimed to investigate the relationship between sociodemographic factors and COVID-19 testing behaviours in England during the COVID-19 pandemic.
View Article and Find Full Text PDFEvaluating Models of the Ageing BOLD Response.
Hum Brain Mapp
October 2024
Wellcome Centre for Human Neuroimaging, University College London, London, UK.
Neural activity cannot be directly observed using fMRI; rather it must be inferred from the hemodynamic responses that neural activity causes. Solving this inverse problem is made possible through the use of forward models, which generate predicted hemodynamic responses given hypothesised underlying neural activity. Commonly-used hemodynamic models were developed to explain data from healthy young participants; however, studies of ageing and dementia are increasingly shifting the focus toward elderly populations.
View Article and Find Full Text PDFArticle Synopsis
- Organismal aging affects various metabolic and functional changes, particularly in the immune system, leading to increased fat in bone marrow, impaired stem cell function, and a bias toward myeloid cell differentiation, which can contribute to diseases like cancer.
- Aging is also linked to lipid changes, including reduced membrane fluidity and shifts in fatty acid profiles, with a focus on how these metabolic changes affect immune cell aging, particularly in hematopoietic cells.
- Research using multi-omics approaches identified a crucial role for a specific polyunsaturated fatty acid biosynthesis gene in aging immune cells, highlighting a loss of B cell markers and lipid alterations in aged mouse models.
CYP1B1-RMDN2 Alzheimer's disease endophenotype locus identified for cerebral tau PET.
Nat Commun
September 2024
Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, USA.
Article Synopsis
- The study investigates the genetic factors contributing to Alzheimer's disease by analyzing tau deposition through a genome-wide association study involving 3,046 participants.
- It identifies the CYP1B1-RMDN2 locus as significantly linked to tau levels, with the variant rs2113389 explaining 4.3% of tau variation, while also correlating with cognitive decline.
- Findings suggest a connection between CYP1B1 expression and tau deposition, offering potential new avenues for Alzheimer's treatment and understanding its genetic basis.
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