Ambient ionization techniques enable the interrogation of a variety of samples in their native state by mass spectrometry, and are rapidly advancing all fields where screening for the presence of various analytes in a broadband and/or high-throughput fashion is desirable. This Highlight article provides an introduction to the field, and showcases the different ionization approaches reported since 2004, with an emphasis on the most recent developments.
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Stylus pen-based ambient ionization mass spectrometry for the analysis of volatiles and semivolatiles from liquid, viscous, and solid samples.
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Department of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan; International College of Semiconductor Technology, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan. Electronic address:
Background: Ambient ionization mass spectrometry (MS) has attracted significant attention due to its simplicity and ease of operation. Contactless, or field-induced, ionization is one of the ambient ionization techniques. In this approach, no direct electrical contact or additional voltage is required on the ionization-assisted substrate.
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Laboratory of Organic Electronics, Department of Science and Technology (ITN), Linköping University, Norrköping SE-60174, Sweden.
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West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
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