Unlabelled: In view of the very limited data about conservative treatment of patients with congenital scoliosis (CS) available, early surgery is suggested already in mild cases with formation failures in the first three years of life. It is common sense that patients with failures of segmentation will not benefit from conservative treatment at all and the same applies to failures of formation with curves of >50 degrees in infancy.
Materials And Methods: Two patients with rib synostosis denied surgery before entering the pubertal growth spurt. These patients have been treated conservatively with braces and Scoliosis In-Patient Rehabilitation (SIR) and now are beyond the pubertal growth spurt. One patient with a formation failure and a curve of >50 degrees lumbar has been treated with the help of braces and physiotherapy from 1.6 years on and is still under treatment now at the age of 15 years.
Results: Severe decompensation was prevented in the two patients with failure of segmentation, however a severe thoracic deformity is evident with underdeveloped lung function and severe restrictive ventilation disorder. The patient with failure of formation is well developed, now without cosmetic or physical complaints although his curve progressed at the end of the growth spurt due to final mal-compliance.
Conclusions: Failures of segmentation should be advised to have surgery before entering the pubertal growth spurt. In case they deny, conservative treatment can at least in part be beneficial. For patients with failures of formation conservative treatment should be suggested in the first place because long-term outcomes of early surgery beyond pubertal growth spurt are not yet revealed.
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Nat Commun
January 2025
Laboratory of Molecular Translational Medicine, Center for Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Pubertal timing is highly variable and is associated with long-term health outcomes. Phenotypes associated with pubertal timing include age at menarche, age at voice break, age at first facial hair and growth spurt, and pubertal timing seems to have a shared genetic architecture between the sexes. However, puberty phenotypes have primarily been assessed separately, failing to account for shared genetics, which limits the reliability of the purported health implications.
View Article and Find Full Text PDFJ Family Med Prim Care
December 2024
Department of Orthopaedics, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.
Primary hyperparathyroidism (PHPT) is relatively uncommon in children, and skeletal deformities due to it are even rarer in this age group. Less than 20 such cases have been reported in the English literature. We describe a case series of three patients who presented with genu valgum deformity and were found to have primary hyperparathyroidism on further evaluation.
View Article and Find Full Text PDFCurr Dev Nutr
December 2024
Department of Population, Family and Reproductive Health, School of Public Health, University of Ghana, Accra, Ghana.
Background: Early and delayed puberty are both associated with adverse health and psychosocial outcomes.
Objectives: We assessed the impact of provision of small-quantity lipid-based nutrient supplement (SQ-LNS) to mothers during pregnancy and 6 mo postpartum and to their children aged 6-18 mo, on pubertal status.
Methods: This study was a follow-up to a partially double-blind randomized controlled trial.
Heliyon
November 2024
Prasad V.Potluri Siddhartha Institute of Technology, Kanuru, Vijayawada, Andhra Pradesh, 520007, India.
This paper proposes Pomarine jaeger Optimization (PJO) algorithm, Tiger hunting Optimization (THO) Algorithm, Desert Reynard and Vixen Inspired Optimization (DRVIO) Algorithm, Lonchodidae optimization (LO) algorithm, Caracal optimization (CO) algorithm, Barasingha optimization (BO) algorithm, Amur leopard optimization (AO) algorithm and Empress SARANI Optimization Algorithm to solve the active power loss reduction problem. Regular actions of Pomarine jaeger have been emulated to model the PJO procedure. In THO algorithm, how the Tiger moves to capture the prey is imitated and formulated.
View Article and Find Full Text PDFSports (Basel)
December 2024
High Performance Sports Laboratory, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
This research aimed to examine the dynamics of changes in sprint and long jump performance and the age of gender divergence in well-trained young athletes specialising in athletics. Data were collected from 1249 male and 1497 female athletes aged 10 to 15 years who participated in the final round of the annual national athletics tournament "Shipovka Yunykh" from 2017 to 2019. The top 50 results in each age group for the 60-metre sprint and long jump were analysed.
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