AI Article Synopsis
- Tet 42 is a recently identified gene linked to tetracycline resistance found in deep subsurface bacteria, showing 30% sequence similarity to the TetA(Z) gene.
- The Tet 42 protein is believed to function as an efflux pump, which helps bacteria remove harmful substances like antibiotics.
- Key features of Tet 42 include a nearby TetR repressor that regulates its activity, a specific conserved sequence motif, and structural components that span cell membranes.
Article Abstract
Tet 42, a novel tetracycline resistance determinant from deep subsurface bacteria, was characterized and found to have a 30% sequence similarity to TetA(Z). The protein is a putative efflux pump that shares characteristics with previously characterized pumps, including a divergently transcribed TetR repressor, a conserved GxxSDRxGRR motif, and transmembrane domains.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592862 | PMC |
| http://dx.doi.org/10.1128/AAC.00640-08 | DOI Listing |
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