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The ISC machinery assembles [2Fe-2S] clusters by formation and fusion of [1Fe-1S] precursors.
Nat Chem Biol
January 2025
Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France.
Iron-sulfur clusters are essential metallocofactors synthesized by multiprotein machineries via an unclear multistep process. Here we report a step-by-step dissection of the [2Fe-2S] cluster assembly process by the Escherichia coli iron-sulfur cluster (ISC) assembly machinery using an in vitro reconstituted system and a combination of biochemical and spectroscopic techniques. We show that this process is initiated by iron binding to the scaffold protein IscU, which triggers persulfide insertion by the cysteine desulfurase IscS upon the formation of a complex with IscU.
View Article and Find Full Text PDFTargeting the initiator to activate both ferroptosis and cuproptosis for breast cancer treatment: progress and possibility for clinical application.
Front Pharmacol
January 2025
Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.
Breast cancer is the most commonly diagnosed cancer worldwide. Metal metabolism is pivotal for regulating cell fate and drug sensitivity in breast cancer. Iron and copper are essential metal ions critical for maintaining cellular function.
View Article and Find Full Text PDFCurculigoside exhibits multiple therapeutic efficacy to induce apoptosis and ferroptosis in osteosarcoma via modulation of ROS and tumor microenvironment.
Tissue Cell
January 2025
Department of Orthopedics, Xijing Hospital, The Air Force Medical University, Xi'an 710032, China. Electronic address:
Objective: Patients with osteosarcoma (OS) exhibit metastasis upon diagnosis, and the condition frequently acquires resistance to traditional chemotherapy treatments, failing the therapy. The objective of this research was to examine the impact of curculigoside (Cur), a key phenolic compound discovered in the rhizome of C. orchioides Gaertn, on OS cells and the surrounding tumor environment.
View Article and Find Full Text PDFUsing monitoring and simulation to analyze the failure characteristics of multizone landslides controlled by faults: a case study.
Sci Rep
January 2025
Information Institute of the Ministry of Emergency Management of PR China, Beijing, 100029, People's Republic of China.
Slopes influenced by multiple faults are prone to large-scale landslides triggered by multi-regional failures. Understanding the failure process and sequence is essential for the sustainable development of mining operations. This paper presents a method combining InSAR monitoring and numerical simulation to analyze the failure processes of slopes affected by multiple faults.
View Article and Find Full Text PDFInvestigating the Pulmonary Host Response of Infection-Associated Pneumonia by Metagenomic Next-Generation Sequencing.
Biomedicines
January 2025
Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
For investigating the host response in associated pneumonia, we analyzed the host genetic sequences obtained from metagenomic next-generation sequencing (mNGS). The samples for mNGS were bronchoalveolar lavage fluid (BALF) collected from the lungs of patients infected with and from patients without bacterial infections. BALF samples from patients with pneumonia were collected from the lungs of patients infected with with New Delhi metallo-β-lactamase (NDM, before treatment), A.
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