An improved protocol for the Pd-catalyzed alpha-arylation of aldehydes with aryl halides has been developed. The new catalytic system allows for the coupling of an array of substrates including challenging electron-rich aryl bromides and less reactive aryl chlorides. The utility of this method has been demonstrated in a new total synthesis of (+/-)-sporochnol.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748776 | PMC |
| http://dx.doi.org/10.1021/ol8017775 | DOI Listing |
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