AI Article Synopsis
- Carotenoids help protect cells from damage caused by light and free radicals, and sigma(F) is essential for their production in Mycobacterium smegmatis.
- A sigF mutant of this bacterium shows a drastically improved transformation efficiency compared to the wild type, indicating that sigma(F) plays a role in regulating factors that affect cell wall permeability.
- Additionally, the sigF mutant is more vulnerable to hydrogen peroxide, with an analysis revealing regulatory sites for SigF near the carotenoid synthesis genes.
Article Abstract
Carotenoids are complex lipids that are known for acting against photodynamic injury and free radicals. We demonstrate here that sigma(F) is required for carotenoid pigment production in Mycobacterium smegmatis. We further show that a sigF mutant exhibits a transformation efficiency 10(4)-fold higher than that of the parental strain, suggesting that sigma(F) regulates the production of components affecting cell wall permeability. In addition, a sigF mutant showed an increased sensitivity to hydrogen peroxide. An in silico search of the M. smegmatis genome identified a number of SigF consensus sites, including sites upstream of the carotenoid synthesis locus, which explains its SigF regulation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583609 | PMC |
| http://dx.doi.org/10.1128/JB.00714-08 | DOI Listing |
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