Objectives: A precise knowledge of the risk factors for childhood and adolescent smoking is crucial for the development of appropriate preventive measures. This study investigated current smoking prevalence and the social and regional correlates for smoking among minors (children and adolescents aged 12-17 years) in Germany.
Methods: Bivariate data analysis was performed on the basis of a representative national cross-sectional study performed in 2004, and multivariable logistic regression models were calculated separately for boys and girls. All correlates identified as significant in the bivariate model were used in the multivariable analysis.
Study Design: The database used in this research was from the study 'Drug Affinity of Young People in the Federal Republic of Germany 2004', with approximately 1298 children and adolescents aged 12-17 years.
Results: Twelve percent of male and 9% of female adolescents in Germany reported that they are habitual smokers, and 12% of male and 13% of female adolescents reported that they are occasional smokers. Multivariable data analysis shows that living in a large city is protective for adolescents in terms of local disparities. The educational level of the respondents also correlates significantly with smoking behaviour. The percentage of adolescent smokers is lowest among those with a high level of education. The presence of smokers in the household is associated with a significantly higher prevalence of smoking among adolescents compared with those growing up in a non-smoking household.
Conclusion: Smoking is a major public health problem among German children and adolescents. Control measures must tackle the structural and social pressures that shape smoking behaviour during childhood.
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http://dx.doi.org/10.1016/j.puhe.2007.12.011 | DOI Listing |
Hum Vaccin Immunother
December 2025
Research and Development, Infectious Disease, Moderna, Inc., Cambridge, MA, USA.
Safety, immunogenicity, and effectiveness of an mRNA-1273 50-μg booster were evaluated in adolescents (12-17 years), with and without pre-booster SARS-CoV-2 infection. Participants who had received the 2-dose mRNA-1273 100-µg primary series in the TeenCOVE trial (NCT04649151) were offered the mRNA-1273 50-μg booster. Primary objectives included safety and inference of effectiveness by establishing noninferiority of neutralizing antibody (nAb) responses after the booster compared with the nAb post-primary series of mRNA-1273 among young adults in COVE (NCT04470427).
View Article and Find Full Text PDFJAMA Pediatr
January 2025
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Importance: Spontaneous reports have indicated that montelukast increases the risk of neuropsychiatric adverse events, and the US Food and Drug Administration added a boxed warning about these risks in 2020. However, the potential mechanism is not well understood, and the observational evidence is scarce, particularly in children.
Objective: To assess the potential association between the use of montelukast and the risk of neuropsychiatric adverse events in children and adolescents.
JAMA Pediatr
January 2025
Division of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Importance: Data regarding the long-term impact of treating childhood obesity on the risk of obesity-related events, including premature mortality, are limited.
Objective: To evaluate the long-term effect of different responses to pediatric obesity treatment on critical health outcomes in young adulthood.
Design, Setting, And Participants: The study included a dynamic prospective cohort of children and adolescents with obesity within The Swedish Childhood Obesity Treatment Register (BORIS) and general population comparators, linked with national registers.
Aging Clin Exp Res
January 2025
Research Laboratory Psychology of Patients, Families, and Health Professionals, Department of Nursing, School of Health Sciences, University of Ioannina, Ioannina, Greece.
Loneliness, social isolation, and living alone are significant risk factors for mortality, particularly in older adults. This systematic review and meta-analysis aimed to quantify their associations with all-cause and cause-specific mortality in older adults, broadening previous research by including more social factors. Comprehensive searches were conducted in PubMed, APA PsycINFO, and CINAHL until December 31, 2023, following PRISMA 2020 and MOOSE guidelines.
View Article and Find Full Text PDFHistochem Cell Biol
January 2025
Department of Histology and Embryology, Faculty of Medicine, Ankara Yildirim Beyazit University, 06800, Ankara, Turkey.
Bone marrow mesenchymal stromal cells (BM-MSCs) are integral components of the bone marrow microenvironment, playing a crucial role in supporting hematopoiesis. Recent studies have investigated the potential involvement of BM-MSCs in the pathophysiology of acute lymphoblastic leukemia (ALL). However, the exact contribution of BM-MSCs to leukemia progression remains unclear because of conflicting findings and limited characterization.
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