A case of congenital, solitary, cutaneous mesenchymal hamartoma in the palm of the left hand is reported. The mass was composed mainly of an intimate mixture of fibrocollagenous bundles and islands of mature fat cells, distorted blood vessels with smooth muscle in the wall, and eccrine sweat glands. Many mast cells were scattered throughout the fibrocollagenous bundles. The mast cell may be an important cell in this hamartoma.
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http://dx.doi.org/10.1016/0363-5023(91)90187-g | DOI Listing |
Int Immunopharmacol
December 2024
Department of Burns and Cutaneous Surgery, Xijing Hospital, the Fourth Military Medical University, 127 Changle West Road, Xi'an, Shaanxi 710032, China. Electronic address:
Acute lung injury being one of the earliest and most severe complications during sepsis and macrophages play a key role in this process. To investigate the regulatory effects and potential mechanisms of adipose mesenchymal stem cell derived-exosomes (ADSC-exo) on macrophages and septic mice, ADSCs-exo was administrated to both LPS-induced macrophage and cecal ligation and puncture (CLP) induced sepsis mice. ADSCs-exo was confirmed to inhibit M1 polarization of macrophages and to reduce excessive inflammation.
View Article and Find Full Text PDFSmall
December 2024
Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems, Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.
Chronic wound poses a serious risk to diabetic patients, primarily due to damaged skin microvasculature and prolonged inflammation at the wound site. Mesenchymal stem cell (MSC) therapy utilizing microgels as a cell delivery system has shown promise in promoting wound healing by enhancing cell viability and the secretion of bioactive factors. Retaining sufficient MSCs at injury sites is crucial for optimal therapeutic outcomes.
View Article and Find Full Text PDFRheumatology (Oxford)
December 2024
Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.
Objectives: Cellular senescence and endothelial-to-mesenchymal transition (EndMT) are profibrotic cellular processes involved in systemic sclerosis (SSc), but how they respond to treatment is largely unknown.
Methods: Skin biopsies from diffuse cutaneous SSc (dcSSc) patients who underwent either autologous haematopoietic stem cell transplantation (aHSCT) or cyclophosphamide pulse (iv CYC) treatment were collected before and 6 months after randomisation in the Autologous Stem Cell Transplantation International Scleroderma (ASTIS) trial. The extent of fibrosis, inflammation, senescence, EndMT and tissue remodelling were examined in histopathology.
Medicina (B Aires)
December 2024
Servicio de Patología, Hospital Interzonal General de Agudos Gral. San Martín, La Plata, Buenos Aires, Argentina.
Superficial angiomyxoma is a benign neoplasm of mesenchymal origin that affects both sexes with a slight predilection for males. It can present in a solitary or multiple form, within the framework of the Carney complex, an autosomal dominant syndrome characterized by the triad: cutaneous and cardiac myxomas, skin pigmentation and endocrine overactivity. They occur more commonly in the head and neck, trunk and lower limbs; the location in the genital region and particularly in the scrotum is very unusual.
View Article and Find Full Text PDFJ Surg Case Rep
December 2024
Department of Otolaryngology, Head & Neck Surgery, University of Cincinnati Medical Center, Cincinnati, OH, United States.
Cutaneous malignancies of the head and neck are common; however, superficial sarcomas of the head and neck are relatively rare. We present a 71-year-old unhoused gentleman with challenging access to medical care and poor health literacy who presented with a large, isolated, pedunculated mass of the left auricular helix. Preoperative biopsy was compatible with pleomorphic dermal sarcoma (PDS).
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