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Neuroglobin-enriched secretome provides neuroprotection against hydrogen peroxide and mitochondrial toxin-induced cellular stress.
Cell Stress
November 2024
Department of Science, Section Biomedical Sciences and Technology, University Roma Tre, V.le G. Marconi Rome, 00146 Italy.
Aberrant response to physiological cell stress is part of the mechanisms underlying the development of diverse human diseases, including neuropathologies. Neuroglobin (NGB), an intracellular monomeric globin, has gained attention for its role in endogenous stress response pathways in neuroprotection. To date, evidence supports the concept of NGB as an inducible protein, triggered by physiological and pathological stimuli via transcriptional and/or post-transcriptional mechanisms, offering cell-autonomous neuroprotective functions under various cellular stresses.
View Article and Find Full Text PDFIntravitreal Neuroglobin Mitigates Primate Experimental Glaucomatous Structural Damage in Association with Reduced Optic Nerve Microglial and Complement 3-Astrocyte Activation.
Biomolecules
June 2023
Department of Ophthalmology, University of Tokyo, Tokyo 113-8654, Japan.
Current management of glaucomatous optic neuropathy is limited to intraocular pressure control. Neuroglobin (Ngb) is an endogenous neuroprotectant expressed in neurons and astrocytes. We recently showed that exogenous intravitreal Ngb reduced inflammatory cytokines and microglial activation in a rodent model of hypoxia.
View Article and Find Full Text PDFNew Strategies for Stroke Therapy: Nanoencapsulated Neuroglobin.
Pharmaceutics
August 2022
Department of Experimental Biology, Campus de Las Lagunillas s/n, University of Jaén, Building B3, 23071 Jaen, Spain.
Stroke is a global health and socio-economic problem. However, no efficient preventive and/or palliative treatments have yet been found. Neuroglobin (Ngb) is an endogen neuroprotective protein, but it only exerts its beneficial action against stroke after increasing its basal levels.
View Article and Find Full Text PDFExpression Pattern of Ngb in Astrocytes after Spinal Cord Injury and the Clinical Significance.
Cell Mol Biol (Noisy-le-grand)
February 2022
Department of Neurosurgery, Xianyang Hospital of Yan'an University, Xianyang, Shaanxi, 712000, China.
In the current study, we evaluated the expression pattern of neuroglobin (Ngb) in the astrocytes after spinal cord injury (SCI) and explore the clinical significance. For this purpose, a total of 48 Sprague-Dawley rats were divided into the SCI group (n = 40) and Sham group (n = 8). Rats in the SCI group were used to prepare the SCI models by using the modified Allen's method, followed by the HE staining to observe the post-SCI pathological changes and immunofluorescent staining to observe the dynamic changes of Ngb in astrocytes after SCI.
View Article and Find Full Text PDFCarbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response.
Pharmacol Rev
July 2022
Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia
Carbon monoxide (CO) has been firmly established as an endogenous signaling molecule with a variety of pathophysiological and pharmacological functions, including immunomodulation, organ protection, and circadian clock regulation, among many others. In terms of its molecular mechanism(s) of action, CO is known to bind to a large number of hemoproteins with at least 25 identified targets, including hemoglobin, myoglobin, neuroglobin, cytochrome c oxidase, cytochrome P450, soluble guanylyl cyclase, myeloperoxidase, and some ion channels with dissociation constant values spanning the range of sub-nM to high M. Although CO's binding affinity with a large number of targets has been extensively studied and firmly established, there is a pressing need to incorporate such binding information into the analysis of CO's biologic response in the context of affinity and dosage.
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