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Artificial Oxygen Carriers Save Lives in Expanded Access Use: Three Cases when Blood Was Not an Option.
Am J Ther
January 2025
Anesthesiology and Perioperative Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Clinical Features: Sickle cell patients may develop a multitude of antibodies and experience life-threatening events with transfusion such as hyperhemolysis syndrome or delayed hemolytic transfusion reaction. Further transfusion may not be possible in such cases.
Therapeutic Challenge: When conventional blood products are not available for transfusion yet the patient requires additional oxygen-carrying support, artificial oxygen carriers may be required.
A New Oxygen Carrier for Therapeutic Applications.
Drug Test Anal
January 2025
Hemarina SA, Aeropôle Centre, Morlaix, France.
The natural extracellular hemoglobin of the lugworm Arenicola marina (AmHb) has many interesting characteristics: It carries 40 times more oxygen than human hemoglobin; has anti-inflammatory, antibacterial, and antioxidant properties; and is 250 times smaller than a red blood cell. It is nontoxic and nonimmunogenic. It is thus a very promising hemoglobin-based oxygen carrier.
View Article and Find Full Text PDFHemoglobin-based oxygen carriers: Biochemical, biophysical differences, and safety.
Transfusion
January 2025
Office of Blood Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland, USA.
Development of hemoglobin microbubbles for acoustic blood oxygen sensing: A study on PEGylation and gas core modification for in vivo applications.
Acta Biomater
December 2024
Department of Bioengineering, Erik Johnson School of Engineering, The University of Texas at Dallas. Electronic address:
The creation of innovative ultrasound contrast agents (UCAs) with the ability to monitor oxygen levels in real-time holds immense potential for advancing early diagnosis of various medical conditions such as hypoxic/reperfusion injury. In this study, we propose the development of oxygen sensitive UCAs using microbubbles composed of hemoglobin (HbMBs), which can function as sensors for blood oxygen levels. Previously, we performed a study highlighting the initial proof-of-concept efficacy of air-filled HbMBs in detecting oxygenation changes in vitro, offering a promising tool for clinically detecting tissue hypoxia.
View Article and Find Full Text PDFArtificial blood-hope and the challenges to combat tumor hypoxia for anti-cancer therapy.
Med Biol Eng Comput
November 2024
Amity Stem Cell Institute, Amity Medical School, Amity University Haryana, Amity Education Valley, Panchgaon, Manesar (Gurugram), Haryana, 122413, India.
Article Synopsis
- - Blood is essential for the body, transporting hormones, regulating temperature and pH, and playing a key role in immune defense and healing through white blood cells and platelets.
- - The circulatory system, made up of arteries, veins, and capillaries, ensures the efficient delivery of nutrients and oxygen but often faces challenges like shortages and compatibility issues, making artificial blood alternatives important.
- - Our study focused on using artificial blood, including red blood cell substitutes and artificial platelets, to improve cancer therapy by addressing issues like tumor hypoxia and enhancing treatment outcomes.
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