Background: Within medical environment, emotional aspect of therapy strategy is frequently ignored or confused with different psychological aspects. There are scarce reports of high-risk pregnancies or recurrent gestational loss, most of them focused on an isolated event or factor related with self-concept.
Objective: To get self-concept profiles in two important reproductive different moments (high-risk pregnancy and recurrent gestational loss) and better focus therapy strategies.
Patients And Methods: Exploratory, transversal, retrospective, non-experimental, descriptive, and closed study. Two hundred patients referred from external consultation at Instituto Nacional de Perinatologia: 100 with high-risk pregnancy (A group), and 100 with recurrent gestational loss history (B group). Pregnant patients must have no abortion history.
Results: Patients with recurrent gestational loss had lower score in every clinical scale, and statistically meaningful differences. Both profiles had peak and sinusoid similarities. Intensity difference was evident and clarifies the psychological dynamics of both contingencies.
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Curr Protoc
January 2025
Myriad Genetic Laboratories, Inc., Salt Lake City, Utah.
Balanced translocation carriers experience elevated reproductive risks, including pregnancy loss and children with anomalies due to generating chromosomally unbalanced gametes. While understanding the likelihood of producing unbalanced conceptuses is critical for individuals to make reproductive decisions, risk estimates are difficult to obtain as most balanced translocations are unique. To improve reproductive risk estimates, Drs.
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Efferocytosis is a mechanism by which phagocytes efficiently clear apoptotic cells, averting their secondary necrosis and the subsequent release of potentially immunogenic or cytotoxic substances that can trigger strong immune and inflammatory responses. During efferocytosis, the metabolic pathways of phagocytes are transformed, which, along with the catabolism of apoptotic cargo, can affect their function and inflammatory state. Extensive apoptosis occurs during placental development, and some studies reported the immunomodulatory effects of efferocytosis at the maternal-fetal interface.
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Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Peking University Third Hospital, State Key Laboratory of Female Fertility Promotion, National Clinical Research Center for Obstetric and Gynecologic Diseases, Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing100191, China.
To explore biomarkers for the efficacy of lymphocyte immunotherapy (LIT) treating women with unexplained recurrent spontaneous abortion (URSA). Serum samples from 24 URSA potients who received LIT were collected at Peking University Third Hospital from December 2014 to June 2015. Semiquantitative sandwich-based antibody arrays containing 40 cytokines were used to screen target immune cytokines in the peripheral blood of URSA patients before and after LIT.
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