Background: Gestational trophoblastic disease (GTD) comprises different types of placental changes distinguished by histologic hydropic degeneration and swelling of chorionic villi.
Objective: To report incidence of gestational trophoblastic disease in a general hospital.
Material And Methods: A cross-sectional study in the period of January 2000 to June 2006 was made. Histopathologic report of specimen abortion with gestational trophoblastic disease was registered and we calculated the incidence of births, abortions and total pregnancies.
Results: In the study period, 142 cases of gestational trophoblastic disease were registered, and an incidence of 1:243 births and 1:31 abortions (1:274 pregnancies) was found. The average age of patients was 27.1 years (15 to 50), 67% of the cases were not clinically suspected.
Conclusions: Histopathologic study of specimen abortions allows calculating precisely incidence of gestational trophoblastic disease, but the findings of this study may be different because numerators and denominators used in the calculation are not the same.
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Circ Res
January 2025
Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada (C.P., S.A., J.W.A., R.L., F.N., J.S., I.C.).
Background: Iron is an essential micronutrient for cell survival and growth; however, excess of this metal drives ferroptosis. Although maternal iron imbalance and placental hypoxia are independent contributors to the pathogenesis of preeclampsia, a hypertensive disorder of pregnancy, the mechanisms by which their interaction impinge on maternal and placental health remain elusive.
Methods: We used placentae from normotensive and preeclampsia pregnancy cohorts, human H9 embryonic stem cells differentiated into cytotrophoblast-like cells, and placenta-specific preeclamptic mice.
J Adv Res
January 2025
Jinxin Research Institute for Reproductive Medicine and Genetics, Sichuan Jinxin Xi'nan Women's and Children's Hospital, Chengdu, China; Provincial Key Laboratory of Molecular Pathology and Personalized Medicine, Center of Collaborative and Creative Center, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, China. Electronic address:
Introduction: Despite of numerous studies of the placenta, some molecular and cellular characteristics, particularly the relationship among different cell types, have not been well understood. We aim to investigate the basic and intricate details of cellular and molecular elements in early and late phase placentas to gain better understanding of the immune regulation of human reproductive process.
Methods: A novel combination of techniques of spatial transcriptomics(ST), multiple immunohistochemistry, and a dual labeling combining immunohistochemistry and (fluorescence in situ hybridization) FISH on normal and ectopic pregnancy and animal models was employed to investigate the placenta at tissue, cell, protein and molecular levels and to trace the fetal and maternal origin of every cell in early and late placentas.
Case Rep Endocrinol
January 2025
Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Graves' disease (GD) and gestational transient thyrotoxicosis (GTT) are the most common causes of thyrotoxicosis during pregnancy, with prevalence ranging from 0.1% to 1% and from 1% to 3%, respectively. Hyperthyroidism during pregnancy can have severe consequences if not promptly recognized and treated.
View Article and Find Full Text PDFToxicol Sci
January 2025
Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Prenatal exposure to the toxic metal inorganic arsenic (iAs) is associated with adverse pregnancy and fetal growth outcomes. These adverse outcomes are tied to physiological disruptions in the placenta. While iAs co-occurs in the environment with other metals such as manganese (Mn), there is a gap in the knowledge of the effects of metal-mixtures on the placenta.
View Article and Find Full Text PDFJ Nanobiotechnology
January 2025
Key Laboratory of Human Genetics and Environmental Medicine, Xuzhou Medical University, Xuzhou, 221004, China.
Fullerenols, a water-soluble polyhydroxy derivative of fullerene, hold promise in medical and materials science due to their unique properties. However, concerns about their potential embryotoxicity remain. Using a pregnancy mouse model and metabolomics analysis, our findings reveal that fullerenols exposure during pregnancy not only significantly reduced mice placental weight and villi thickness, but also altered the classes and concentrations of metabolites in the mouse placenta.
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