AI Article Synopsis
- A linear relationship was established between the amount of penicillin-binding protein 2a (PBP 2a) and membrane proteins in MRSA COL using dot-blot analysis.
- The study measured PBP 2a quantities in membrane fractions from 14 different MRSA strains, with methicillin-sensitive S. aureus ATCC 6538P serving as a quality control.
- Results showed variation in PBP 2a amounts across strains, with no correlation found to beta-lactam minimum inhibitory concentration (MIC) values.
Article Abstract
After establishing a linear relationship between the amount of penicillin-binding protein (PBP) 2a and membrane proteins of methicillin-resistant Staphylococcus aureus (MRSA) COL by dot-blot analysis using an antibody against PBP 2a, we determined the PBP 2a quantities in membrane fractions prepared from 14 different MRSA cells. Methicillin-sensitive S. aureus ATCC 6538P was used as a quality control strain. The amounts of PBP 2a diverged among the strains, and no relationship to beta-lactam MIC values were observed in the corresponding strains.
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| http://dx.doi.org/10.2152/jmi.55.246 | DOI Listing |
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