Palifermin is a human keratinocyte growth factor that is efficacious in reducing duration and severity of oral mucositis during autologous haematopoietic stem-cell transplantation for haematological cancer as well as chemotherapy for colorectal cancers. We report the clinical and histological characteristics of a series of five patients who developed flexural hyperpigmentation after treatment with palifermin. All patients showed ill-defined symmetrical hyperpigmented papillomatous plaques with slight erythema in the skin folds, especially affecting axillary and inguinal areas. The most striking histological finding was the thickened granular layer in all patients. We demonstrate that filaggrin, an essential component in the terminal differentiation of the epidermis, was upregulated in these cases. Palifermin-induced flexural hyperpigmentation is a newly defined clinical and histological entity. The possible aetiology is discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1365-2133.2008.08816.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Presentations of Cutaneous Disease in Various Skin Pigmentations: Chronic Atopic Dermatitis.
HCA Healthc J Med
April 2024
Medical City Fort Worth, Fort Worth, TX.
Article Synopsis
- Atopic dermatitis is a long-lasting skin condition that commonly affects the inner elbows and behind the knees, impacting both kids and adults, including those with darker skin tones.
- The skin presents as dry, cracked, and discolored patches that may become thickened (lichenified).
- The article will feature clinical images that demonstrate different appearances of chronic atopic dermatitis across various ages and skin types, using the Fitzpatrick scale for reference.
Galli-Galli Disease: A Comprehensive Literature Review.
Dermatopathology (Basel)
February 2024
Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy.
Article Synopsis
- Galli-Galli disease (GGD) is a rare genetic skin disorder characterized by red spots, bumps, and a distinct pigmented pattern primarily in skin folds, and presents in both typical and atypical forms.
- The review analyzes cases of GGD since its identification in 1982, covering aspects like causes, how it appears, diagnosis, and treatment options.
- It highlights the similarities between GGD and another skin condition, Dowling-Degos disease (DDD), suggesting they might be different expressions of the same genetic issue, while also noting the lack of effective treatment guidelines for GGD.
Hyperpigmented Flexural Plaques, Hypohidrosis, and Hypotrichosis.
Cutis
November 2023
Dr. Loyd is from the University of Oklahoma College of Medicine, Oklahoma City. Drs. Weissman and Levin are from the Department of Dermatology, University of Oklahoma Health, Oklahoma City.
A comparison of the efficacy and safety profiles of 10% salicylic acid and 10% urea creams in treating acanthosis nigricans in adolescents: a randomized double-blinded study.
Arch Dermatol Res
September 2023
Department of Pediatrics, Faculty of Medicine, Srinakharinwirot University, HRH Princess Maha Chakri Sirindhorn Medical Center, Rangsit-Nakhonnayok Road, Ongkharak, 26120, Nakhonnayok, Thailand.
Acanthosis nigricans is characterized by the presence of velvety hyperpigmentation of the skin over the neck and the flexural areas. Regardless of different modalities of treatment, none provides a definite standard cure. This study aims to assess the efficacy of topical 10% salicylic acid compared to 10% urea cream in treating acanthosis nigricans in adolescents.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!