Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Targeting metabolic reprogramming to overcome drug resistance in advanced bladder cancer: insights from gemcitabine- and cisplatin-resistant models.
Mol Oncol
September 2024
Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.
Article Synopsis
- * Studies revealed that gemcitabine-resistant cells have higher levels of phosphoglycerate dehydrogenase (PHGDH) and altered metabolic pathways, which enhance survival and growth despite treatment.
- * Targeting PHGDH and combining a specific tyrosine kinase inhibitor with other treatments showed promising results in reducing tumor growth and promoting cell death in resistant bladder cancer cells in laboratory tests.
State-of-art review: intravascular imaging in percutaneous coronary interventions.
Cardiol Plus
January 2024
The Division of Cardiology, Department of Medicine, John Cochran Veterans Affairs Medical Center, St. Louis, MO 63106, USA.
The history of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) reflects the relentless pursuit of innovation in interventional cardiology. These intravascular imaging technologies have played a pivotal role in our understanding of coronary atherosclerosis, vascular pathology, and the interaction of coronary stents with the vessel wall. Two decades of clinical investigations demonstrating the clinical efficacy and safety of intravascular imaging modalities have established these technologies as staples in the contemporary cardiac catheterization lab's toolbox and earning their place in revascularization clinical practice guidelines.
View Article and Find Full Text PDFLC-MS/MS analysis of coccidiostats in meat supply chain safety.
J Mass Spectrom
January 2024
Biochemie Lab S.r.l., Via di Limite 27G, Campi Bisenzio (FI), 50013, Italy.
The presence of coccidiostats in meat products represents an important topic because of the animal administration of these substances, authorized as feed additives for targeted species, in order to prevent and inhibit coccidiosis. Coccidiostats include both ionophores and synthetic molecules characterized by different chemical-physical properties such as polarity. Meat is a matrix characterized by many interfering compound groups, such as proteins, phospholipids, and fats.
View Article and Find Full Text PDFThe Minimum Methionine Requirement for Adults Aged ≥60 Years Is the Same in Males and Females.
Nutrients
September 2023
Research Institute, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
The minimum methionine requirement in the presence of excess dietary cysteine has not been determined in older adults. This study aimed to determine the minimum methionine requirement in healthy older adults using the indicator amino acid oxidation (IAAO) method. Fifteen healthy adults ≥ 60 years of age received seven methionine intakes (0 to 20 mg/kg/d) plus excess dietary cysteine (40 mg/kg/d).
View Article and Find Full Text PDFDespite being under development for decades, RNA therapeutics have only recently emerged as viable drug platforms. The COVID-19 mRNA vaccines have demonstrated the promise and power of the platform technology. In response, novel RNA drugs are entering clinical trials at an accelerating rate.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!