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Milestone events in recessive dystrophic epidermolysis bullosa (RDEB): findings of the PEBLES Study.
Clin Exp Dermatol
January 2025
St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Background: In recessive dystrophic epidermolysis bullosa (RDEB), complications like oesophageal strictures, hand contractures, cardiomyopathy and cutaneous squamous cell carcinoma (SCC) may develop, necessitating procedures such as oesophageal dilatation (OD), gastrostomy tube placement and hand surgery.
Objectives: To determine prevalence and age of onset of milestone events by RDEB subtype, specifically dysphagia, first OD, first gastrostomy tube, first hand surgery, cardiomyopathy, first SCC and death.
Methods: The Prospective Epidermolysis Bullosa Longitudinal Evaluation Study (PEBLES) is a register study of individuals with RDEB which records comprehensive EB- and non-EB-related health information.
Meta Analysis of Efficacy and Safety of Prostate Biopsy: A Comparison Between Transperineal and Transrectal Approach.
Urol Res Pract
January 2025
Department of Urology, Universitas Sumatera Utara Hospital - Universitas Sumatera Utara, Indonesia.
Improved prostate biopsy procedures have been developed to overcome traditional limitations, aiming to enhance cancer diagnosis accuracy. To assess the existing knowledge of the effectiveness and risks linked to transperineal (TP) vs. transrectal (TR) prostate biopsy.
View Article and Find Full Text PDFBlood culture isolates and antimicrobial sensitivities from 1621 critically ill neonatal foals (2005-2022).
Aust Vet J
January 2025
Scone Equine Hospital, 406 Bunnan Road, Scone, New South Wales, Australia.
Introduction: Sepsis is a leading cause of morbidity and mortality in neonatal foals. Administration of appropriate antimicrobials and early aggressive supportive treatment is central to the efficacious treatment of neonatal sepsis and has proven to positively influence outcomes. The primary aim of our study was to evaluate microorganism results and antimicrobial sensitivities of neonatal foals with a positive blood culture submitted to our intensive care unit (ICU) during 2005-2022.
View Article and Find Full Text PDFidentification through bronchoscope in intensive care unit - a retrospective, databased cohort study.
Front Cell Infect Microbiol
January 2025
Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Introduction: Invasive pulmonary aspergillosis (IPA) increases the risk of mortality of critically ill patients. Diagnostic criteria specifically targeting patients in intensive care units(ICUs) have been developed to improve diagnostic sensitivity. This study investigated health outcomes among patients in ICUs with Aspergillus isolates identified using bronchoscopy.
View Article and Find Full Text PDFDevelopment and internal validation of a metabolism-related model for predicting 30-day mortality in neonatal sepsis.
BMC Infect Dis
January 2025
Neonatal intensive care Unit, GanZhou Women and Children's Health Care Hospital, GanZhou, Jiangxi, China.
Objective: Neonatal sepsis, a severe infectious disease associated with high mortality rates, is characterized by metabolic disturbances that play a crucial role in its progression. The aim of this study is to develop a metabolism-related model for assessing 30-day mortality in neonatal sepsis.
Methods: The clinical data of neonatal sepsis at Ganzhou Women and Children's Health Care Hospital from January 2019 to December 2022 were retrospectively analyzed.
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