AI Article Synopsis
- A new method for synthesizing benzene ring acylated and demethylated harmine analogues has been developed, using acyl halides or acid anhydrides and aluminum chloride without solvents, at room temperature.
- This method produced a variety of products, including monoacyl and diacyl derivatives, through the use of eight different acyl compounds.
- The overall yields for the 29 different products ranged from 6% to 34%, and all compounds were thoroughly characterized post-synthesis.
Article Abstract
A simple, rapid, solvent-free, room temperature one pot synthesis of benzene ring acylated and demethylated analogues of harmine using acyl halides/acid anhydrides and AlCl(3) has been developed. Eight different acyl halides/acid anhydrides were used in the synthesis. The resulting mixture of products was separated by column chromatography to afford 10- and 12-monoacyl analogues, along with 10,12-diacyl-11-hydroxy products. In five cases the corresponding 10-acyl-11-hydroxy analogues were also obtained. Yields from the eight syntheses (29 products in total) were in the 6-34% range and all compounds were fully characterized.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245451 | PMC |
| http://dx.doi.org/10.3390/molecules1301584 | DOI Listing |
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