This study demonstrated effects of age, education, and sex on complex reaction time in a large national sample (N = 3,616) with a wide range in age (32-85) and education. Participants completed speeded auditory tasks (from the MIDUS [Midlife in the U.S.] Stop and Go Switch Task) by telephone. Complexity ranged from a simple repeated task to an alternating task that involved central executive processes including attention switching and inhibitory control. Increased complexity was associated with slower responses in older adults, those with lower education, and women, even after controlling for differences in health status. Higher levels of education were associated with greater central executive efficiency across adulthood: Overall, adults with college degrees performed on complex tasks like less educated individuals who were 10 years younger, up to age 75. These findings suggest that advanced education can moderate age differences on complex speeded tasks that require central executive processes, at least up to the point in old age at which biological declines predominate. The approach demonstrates the utility of combining laboratory paradigms with survey methods to enable the study of larger, more diverse and representative samples across the lifespan.
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http://dx.doi.org/10.1037/a0012845 | DOI Listing |
PLoS One
January 2025
Department of Anorectal Surgery, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Introduction: Intestinal constipation is a substantive global health concern, significantly impairing patient quality of life. An emerging view is that the gut microbiota plays a critical role in intestinal function, and probiotics could offer therapeutic benefits. This study aims to consolidate evidence from randomized controlled trials (RCTs) that assess the effectiveness of probiotics in modulating microbiota and ameliorating symptoms of constipation.
View Article and Find Full Text PDFDrug Deliv Transl Res
January 2025
Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Northeastern University, Boston, MA, 02115, USA.
Age-related macular degeneration (AMD) is one of the leading causes of central vision loss in the elderly population. Bevacizumab, a full-length humanized monoclonal anti-VEGF antibody, is commonly used off-label drug to treat AMD. However, the dosing regimen of bevacizumab and other anti-VEGF antibodies requires monthly intravitreal injections followed by regular intravitreal injections at 4-16-week intervals.
View Article and Find Full Text PDFJ Intell
January 2025
School of Labor and Employment Relations, University of Illinois Urbana-Champaign, Champaign, IL 61820, USA.
Complex problem solving (CPS) refers to a set of higher-order capacities that allow an individual to interact with a dynamic environment and solve complex problems. The purpose of this study was to develop and validate Sokoban, a game-based assessment of the planning-execution stage of the CPS framework proposed by PISA 2012. The psychometric properties of this instrument were examined in a large sample of Chinese students ( = 1145) ranging from elementary to tertiary education.
View Article and Find Full Text PDFBrain Sci
December 2024
Department of Philosophy, Social Sciences & Education, University of Perugia, Piazza G. Ermini 1, 06123 Perugia, Italy.
Attention is a complex process involving various components such as alerting, orienting, and resolving conflicts. These components have been widely examined using the Attention Network Test (ANT), which has also been used to explore attentional decline associated with aging. However, discrepancies exist in the literature regarding which specific aspects of attention are most impacted by aging.
View Article and Find Full Text PDFFront Public Health
January 2025
The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China.
Objective: This study aims to investigate the perceived benefits, costs, and relationships that influence doctors' inclination to participate in urban-rural medical consortia (URMC). Furthermore, the study analyzes how perceived relationships moderate the impact of perceived benefits and costs on the inclination to take part in URMC.
Methods: The study was conducted between September 2022 and June 2023 utilizing an online survey in Henan Province, Central China, which included 749 respondents from provincial hospitals.
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